Objective: Event-related desynchronization (ERD) and synchronization (ERS) were studied during an auditory-verbal working memory task in patients suffering from Parkinson's disease (PD).
Methods: PD patients (n=7, mean age 59) at a mild stage of the disease volunteered in the study. A group of healthy subjects (n=10, mean age 61) served as control group. ERD and ERS of the 1-25 Hz EEG frequencies were studied using wavelet transforms during memory encoding and retrieval.
Results: Both groups performed equally well on the memory task. Statistically significant differences in ERD/ERS responses were observed in posterior electrodes during encoding of the memory set due to the fact that alpha ( approximately 10-15 Hz) ERS was elicited in the controls, but not in the PD group. In broad frequency bands ( approximately 6-25 Hz) ERD responses were observed in both groups during memory retrieval. A pre-stimulus alpha ERS seen in the control group was absent in the PD group.
Conclusions: The results of this preliminary study indicate that Parkinson's disease might affect brain oscillatory responses in the alpha frequency range in the encoding phase of auditory-verbal working memory.
Significance: The ERD/ERS patterns may reflect neurophysiological alterations in the processes underlying working memory deficits in PD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinph.2006.05.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic Heterogeneity in Four Probands Reveals , , and Related Neurodevelopmental Disorders.
Biomedicines
November 2024
Translational Genomics Laboratory, Department of Biosciences, COMSATS University, Islamabad 45550, Pakistan.
: Neurodevelopmental disorders of genetic etiology are a highly diverse set of congenital recurrent complications triggered by irregularities in the basic tenets of brain development. : We present whole exome sequencing analysis and expression characteristics of the probands from four unrelated Pakistani consanguineous families with facial dysmorphism, neurodevelopmental, ophthalmic, auditory, verbal, psychiatric, behavioral, dental, and skeletal manifestations otherwise unexplained by clinical spectrum. : Whole exome sequencing identifies a novel, bi-allelic, missense variant in the gene [NM_152419.
View Article and Find Full Text PDFMapping cognitive dysfunction in relapsing multiple sclerosis with mild disability: A cross-sectional study from South India.
Mult Scler J Exp Transl Clin
December 2024
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Background: Cognitive dysfunction in multiple sclerosis (MS) occurs early. Locally adapted neuropsychological data from India in MS is scarce.
Objectives: We aimed to identify the pattern of cognitive impairment in relapsing MS (RMS) with mild disability using a regionally-adapted MS-specific cognitive battery.
Predicting Progression to Dementia Using Auditory Verbal Learning Test in Community-Dwelling Older Adults Based On Machine Learning.
Am J Geriatr Psychiatry
November 2024
Hubei Provincial Clinical Research Center for Alzheimer's Disease (XYX, LYH, DL, GRC, FFH, JZ, JJZ, GBH, JWG, XCL, JYW, DYZ, JL, QQN, DS, SYL, CC, YYC, LX, YMO, XXC, YLZ, YSC, JQL, ZW, QW, YFM, YZ), Tian You Hospital Affiliated to Wuhan University of Science and Technology, Wuhan; Geriatric Hospital Affiliated to Wuhan University of Science and Technology (XYX, DL, GRC, FFH, LX, YMO, XXC, YLZ, JQL, QW, YFM, WT, YZ), Wuhan; School of Public Health (XYX, DL, LX, YMO, YSC, JQL, ZW, YZ), Wuhan University of Science and Technology, Wuhan. Electronic address:
Article Synopsis
- This study focused on creating machine learning models to identify predictive features of dementia in older adults who initially showed normal cognition.
- Four models were developed and tested, with the random forest model showing the highest accuracy (93%) using factors like memory test results, education, and follow-up time.
- The findings suggest that this machine learning approach can effectively predict dementia in primary healthcare settings, helping to track cognitive changes and enable early intervention.
Caregiver Burden and Its Associated Factors Among Family Caregivers of Hospitalized Patients with Neurocritical Disease: A Cross-Sectional Study.
J Multidiscip Healthc
November 2024
School of Nursing, Army Medical University (Third Military Medical University), Chongqing, 434008, People's Republic of China.
Background: Providing informal care for patients with neurocritical diseases is a challenging job, and family caregivers usually experience psychological distress and high caregiver burden. Previous studies have focused on caregiver burden for patients in the home rehabilitation stage, while few studies investigate caregiver burden among informal caregivers of early postoperative inpatients.
Objective: This study aimed to investigate caregiver burden for caregivers of patients with neurocritical diseases during hospitalization and to identify predictive factors related to caregiver burden.
Assessing spatial memory using the Brown Location Test: Lateralizing seizures in a presurgical cohort of patients with temporal lobe epilepsy.
Epilepsy Behav
December 2024
School of Psychological Sciences, Macquarie University, Sydney, Australia; Comprehensive Epilepsy Service, Westmead Hospital, Sydney, Australia. Electronic address:
Article Synopsis
- The study investigates the role of the nondominant temporal lobe in memory by comparing a spatial memory task (Brown Location Test, BLT) with verbal and visual memory tasks in patients with temporal lobe epilepsy (TLE).
- Results showed that patients with right TLE specifically struggled with the BLT, while those with left TLE had difficulties with both verbal and nonverbal tasks.
- Combining BLT Delayed Recall and Rey Auditory Verbal Learning Task (RAVLT) scores was found to be the best way to predict the lateralization of the epileptogenic zone, showing the importance of using diverse memory assessments for evaluating epilepsy surgery candidates.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!