AI Article Synopsis
- Vitamin C plays a crucial role in skin health through collagen synthesis, depigmentation, and antioxidant effects, but it is highly unstable in various conditions, necessitating effective antioxidant systems for stability in cosmetic products.
- The research aimed to develop O/W emulsions and aqueous gels containing vitamin C, testing the effects of antioxidants sodium metabisulfite (SMB) and glutathione (GLT) on its stability.
- Stability tests showed that formulations with SMB or GLT maintained over 90% of vitamin C content under controlled conditions, confirming that these antioxidants are essential for preserving vitamin C in cosmetics.
Article Abstract
Vitamin C exerts several functions on skin as collagen synthesis, depigmentant and antioxidant activity. Vitamin C is unstable in the presence of oxygen, luminosity, humidity, high temperatures and heavy metals, which presents a significant challenge to the development of cosmetic formulations. Therefore, the utilization of an effective antioxidant system is required to maintain the vitamin C stability. The purpose of this research work was to develop prototypes of cosmetic formulations, as O/W emulsion and extemporaneous aqueous gel, containing vitamin C and to evaluate the influence of sodium metabisulfite (SMB) and glutathione (GLT), as antioxidants, on the stability of the active substance. A HPLC stability-indicating method was developed and validated for this study and stability assays were performed in 90 and 26 days and storage conditions were 5.0+/-0.5, 24+/-2 and 40.0+/-0.5 degrees C. The HPLC stability-indicating method showed linearity (r(2)>0.99), specificity, R.S.D.<1.22% and accuracy/recovery ranging from 95.46 to 101.54%. Preparations with SMB or GLT and the antioxidant-free presented results statistically distinct, demonstrating the necessity of the antioxidant system addition. O/W emulsions with SMB or GLT retained the vitamin C content >90.38% stored at 5.0+/-0.5 and 24+/-2 degrees C. For the aqueous gel with SMB or GLT, the active substance concentration was maintained >94.03%. Considering the vitamin C stability, the SMB and the GLT showed to be statistically adequate, as antioxidants, for the cosmetic formulations.
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| http://dx.doi.org/10.1016/j.ijpharm.2006.05.038 | DOI Listing |
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