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Generating Self-Adjuvated Nanofiber Vaccines by Coating Bacterial Flagella with Antigens.
Adv Mater
February 2025
Shanghai Frontiers Science Center of Drug Target ldentification and Delivery，School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Bacteria-based vaccines have received increasing attention given the ability to induce strong systemic immune responses. However, the application of bacteria as therapeutic agents inevitably suffers from infection-associated side effects due to the living characteristics. Here, the use of bacteria-derived flagella is described to construct self-adjuvated nanofiber vaccines.
View Article and Find Full Text PDFAlgaeSperm: Microalgae-Based Soft Magnetic Microrobots for Targeted Tumor Treatment.
Small
January 2025
School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.
Magnetic microrobots are significant platforms for targeted drug delivery, among which sperm-inspired types have attracted much attention due to their flexible undulation. However, mass production of sperm-like soft magnetic microrobots with high-speed propulsion is still challenging due to the need of more reasonable structure design and facile fabrication. Herein, a novel strategy is proposed for large-scale preparation of microalgae-based soft microrobots with a fully magnetic head-to-tail structure, called AlgaeSperm with robust propulsion and chemo-photothermal performance.
View Article and Find Full Text PDFFlagellar rotation facilitates the transfer of a bacterial conjugative plasmid.
EMBO J
January 2025
Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, POB 12272, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel.
Article Synopsis
- Conjugation-mediated DNA delivery is a key way antibiotic resistance spreads among bacteria, but the details of how this process works are not well understood.
- The pLS20 plasmid, found in Bacillus species, uniquely requires fluid environments and induces multicellular clustering to enhance DNA transfer.
- This study found that the pLS20 plasmid’s gene expression relies on the presence of bacterial flagella, connecting motility with the activation of conjugation during active movement, potentially spreading the plasmid to new areas.
The Gene Cluster - Negatively Regulates Biofilm Formation in .
Int J Mol Sci
November 2024
School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, China.
() is a zoonotic foodborne pathogen that is widely distributed worldwide. Its optimal growth environment is microaerophilic conditions (5% O, 10% CO), but it can spread widely in the atmospheric environment. Biofilms are thought to play an important role in this process.
View Article and Find Full Text PDFDelivering large genes using adeno-associated virus and the CRE-lox DNA recombination system.
Hum Mol Genet
December 2024
Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, 375 Newton Road, Iowa City, IA 52242, United States.
Adeno-associated virus (AAV) is a safe and efficient gene delivery vehicle for gene therapies. However, its relatively small packaging capacity limits its use as a gene transfer vector. Here, we describe a strategy to deliver large genes that exceed the AAV's packaging capacity using up to four AAV vectors and the CRE-lox DNA recombination system.
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