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Emerging paradigm: Molecularly targeted therapy with Dabrafenib and Trametinib in recurring pediatric gliomas with BRAF mutations: A narrative review.
Medicine (Baltimore)
December 2024
Faculty of Medicine and Health Sciences, University of Bakht Alruda, Ad Duwaym, Sudan.
Gliomas are tumors arising in the central nervous system, frequently associated with Class I mutations and BRAF fusions. These mutations are adverse prognostic factors in juvenile gliomas, leading to high rates of recurrence and poor response to current treatments. The blood-brain barrier and the heterogeneity of gliomas complicate the development of a single treatment strategy for all cases.
View Article and Find Full Text PDFMorphological and Prognostic Values of Skin Lesions in Patients with COVID-19.
Dermatol Res Pract
October 2024
Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
The dermatological manifestations of the coronavirus cause severe acute respiratory syndrome. The current study investigates the morphological and histopathological relationship between the emergence of skin lesions and the severity of COVID-19 across the course of the disease via a cross-sectional study. There were skin lesions (maculopapular rash, vesiculobullous lesions, urticarial lesions, cutaneous thromboembolic "CT," and erythema multiforme-like lesions "EM-like") in confirmed COVID-19 instances.
View Article and Find Full Text PDFFavorable Prognosis in Patients With Multiple Myeloma and Lenalidomide-Induced Skin Rash: A Multicenter Retrospective Study.
Eur J Haematol
October 2024
Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Although lenalidomide is an essential treatment for multiple myeloma (MM), skin rashes are a common adverse event. This retrospective study aimed to examine the association between skin rash development during lenalidomide treatment and the prognosis of relapsed/refractory MM. All patients who received lenalidomide at 10 hospitals between July 2009 and December 2015 were included in the study.
View Article and Find Full Text PDFAn Observational Study on the Clinical Characteristics and Prognosis of Patients With Interstitial Lung Disease Secondary to Dermatomyositis and Antisynthetase Syndrome.
Int J Rheumatol
September 2024
Department of Rheumatology and Immunology The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province 530021, China.
Article Synopsis
- - The study analyzed clinical characteristics and prognostic factors of patients with idiopathic inflammatory myopathy (IIM) who also had interstitial lung disease (ILD) and included 39 males and 111 females with a mean onset age of 50.4 years and a median disease duration of 3 months.
- - Among the patients, 97 had dermatomyositis (DM-ILD) and 53 had antisynthetase syndrome (ASS-ILD), with DM-ILD patients showing higher rates of anti-MDA5 antibodies and common symptoms such as skin ulcers and rapidly progressing ILD, while ASS-ILD patients showed higher rates of anti-Jo-1 antibodies and pericardial effusion.
Nailfold Capillaroscopy Changes in Patients with Idiopathic Inflammatory Myopathies.
J Clin Med
September 2024
Faculty of Medicine, Institute of Rheumatology, University of Belgrade, 11000 Belgrade, Serbia.
Article Synopsis
- Idiopathic inflammatory myopathies (IIMs) are unique autoimmune disorders causing muscle weakness and additional symptoms, with recent criteria defining their subgroups for better classification.
- This study involved 90 IIM patients and a control group, assessing nailfold capillaroscopy (NFC) patterns and their correlation with clinical signs to identify diagnostic potential across different IIM types.
- Results showed a high incidence of scleroderma capillaroscopic patterns in dermatomyositis and amyopathic dermatomyositis, indicating NFC's usefulness in discerning IIM subtypes and linking them to specific clinical features.
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