Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1592/phco.26.7.1049 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Regulation of human Th9 cell differentiation by lipid modulators targeting PPAR-γ and acetyl-CoA-carboxylase 1.
Front Immunol
January 2025
Department of Pharmaceutical Sciences, Marshall University School of Pharmacy, Huntington, WV, United States.
CD4 T cell activation induces dramatic changes to cellular metabolism for supporting their growth and differentiation into effector subsets. While the cytokines IL-4, TGF-β and IL-21 promote differentiation into Th9 cells, metabolic factors regulating this process remain poorly understood. To assess the role of lipid metabolism in human Th9 cell differentiation, naïve CD4 T cells were purified from blood of healthy volunteers and cultured in the presence or absence of compounds targeting PPAR-γ, acetyl-CoA-carboxylase 1 (ACC1), and AMP-activated protein kinase (AMPK) for four days.
View Article and Find Full Text PDFRosiglitazone-induced white adipocyte browning is regulated by actin and Myh9.
Life Sci
December 2024
Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Frontiers Science Center for Animal Breeding and Sustainable Production, Wuhan, Hubei 430070, China; Hubei Hongshan Laboratory, Wuhan, Hubei 430070, China. Electronic address:
Aims: This study investigates the role of actin polymerization and Myh9 in mediating lipid droplet (LD) fission during rosiglitazone-induced browning of white adipocytes. The aim is to understand how LD splitting might contribute to the beige conversion of white adipose tissue, providing insights into adipocyte plasticity and metabolic regulation.
Materials And Methods: C3H10 T1/2-differentiated adipocytes were used as a classical model to study white adipocyte browning.
Antioxidant effects of a novel pioglitazone analogue (PA9) in a rat model of diabetes: Modulation of redox homeostasis and preservation of tissue architecture.
J Diabetes Complications
December 2024
Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Oxygen-free radicals have been implicated in the initiation of diabetic complications. Thiazolidinediones (TZDs), known for their antidiabetic properties, also demonstrate notable antioxidant and anti-inflammatory effects. Although a recently developed imidazolyl analogue of pioglitazone (PA9) has exhibited superior glucose-lowering efficacy compared to pioglitazone, its antioxidant effects remain unexplored.
View Article and Find Full Text PDFRegulation of renal ischemia-reperfusion injury and tubular epithelial cell ferroptosis by pparγ m6a methylation: mechanisms and therapeutic implications.
Biol Direct
October 2024
Department of Transfusion Medicine, Key Laboratory of Jiangxi Province for Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwai Zhengjie, Nanchang, 330006, Jiangxi Province, China.
Article Synopsis
- - This study investigates how Peroxisome proliferator-activated receptor gamma (PPARγ) and its m6A methylation influence kidney damage from ischemia-reperfusion (I/R) injury and the related cell death process known as ferroptosis.
- - Researchers used RNA sequencing and various experimental techniques to explore the effects of the PPARγ activator Rosiglitazone, and how the proteins METTL14 and IGF2BP2 regulate PPARγ expression during renal injury.
- - Their findings indicate that m6A methylation of PPARγ, controlled by METTL14 and reliant on IGF2BP2, is crucial in reducing kidney damage and ferroptosis in tubular epithelial cells,
Pioglitazone attenuates behavioral and electrophysiological dysfunctions induced by two-hit model of schizophrenia in adult rodent offspring.
Eur Neuropsychopharmacol
December 2024
Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
Article Synopsis
- * Anti-inflammatory drugs like PPARγ agonists, particularly pioglitazone, may help prevent schizophrenia by reducing inflammation triggered by maternal poly(I:C) injections and stress in offspring.
- * Pioglitazone was shown to decrease inflammation in microglia without harming their ability to engulf pathogens and prevented social and cognitive deficits in animals exposed to maternal and stress factors.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!