The dense flow of air bubbles in a two-dimensional silo (through an aperture D) filled with a liquid is studied experimentally. A particle tracking technique has been used to bring out the main properties of the flow: displacements of the bubbles, transverse, and axial velocities. The behavior of the air bubbles is observed to present similarities with nondeformable solid grains in a granular flow. Nevertheless, a correlation between the bubble velocities and their deformations has been evidenced. Moreover, a new discharge law (Beverloo like) must be considered for such a system, where the flow rate is observed to vary as D(1/2) and depends on the deformability of the particles.
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http://dx.doi.org/10.1103/PhysRevE.73.056309 | DOI Listing |
J Pharm Sci
January 2025
Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Protein aggregation, a major concern in biopharmaceutical quality control, can be accelerated by various stresses during clinical handling. This study investigated potential aggregation risk factors during dilution process with syringe handling for intravenous administration. Using γ-globulin and IgG solutions as surrogate models of antibody therapeutics, we examined the effects of high sliding speeds and piston operations of the syringe on protein aggregation during saline dilution.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Department of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp. Al., 70-111 Szczecin, Poland.
Biosensors are transforming point-of-care diagnostics by simplifying the detection process and enabling rapid, accurate testing. This study introduces a novel, reusable biosensor designed for direct viral RNA detection from unfiltered saliva, targeting SARS-CoV-2. Unlike conventional methods requiring filtration, our biosensor leverages a unique electrode design that prevents interference from saliva debris, allowing precise measurements.
View Article and Find Full Text PDFMicromachines (Basel)
January 2025
College of Naval Architecture and Shipping, Guangdong Ocean University, Zhanjiang 524088, China.
In recent years, liquid-solid triboelectric nanogenerators (L-S TENGs) have been rapidly developed in the field of liquid energy harvesting and self-powered sensing. This is due to a number of advantages inherent in the technology, including the low cost of fabricated materials, structural diversity, high charge-energy conversion efficiency, environmental friendliness, and a wide range of applications. As liquid phase dielectric materials typically used in L-S TENG, a variety of organic and inorganic single-phase liquids, including distilled water, acidic solutions, sodium chloride solutions, acetone, dimethyl sulfoxide, and acetonitrile, as well as paraffinic oils, have been used in experiments.
View Article and Find Full Text PDFIntroduction: With the increasing use of aeromedical transport for critically ill patients, it is essential to understand the impact of pressure changes on drug infusion delivery systems. As airplanes ascend and descend, gases/bubbles are released from solutions when ambient pressure decreases and dissolves when pressure increases. This may affect mechanical fluid delivery systems and cause clinically significant changes, especially within a critical care setting.
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
We report an experimental study on how topological defects induced by cylindrical air inclusions in the ferroelectric nematic liquid crystal RM734 are influenced by ionic doping, including an ionic surfactant and ionic polymer. Our results show that subtle differences in molecular structure can lead to distinct surface alignments and topological defects. The ionic surfactant induces a planar alignment, with two -1/2 line defects adhering to the cylindrical bubble surface.
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