We present a model of microfluidic flow of several completely immiscible fluids and use it to simulate a whole flow focusing device chamber. Our efficient, practical model supports a large parameter space, spanned by surface wetting, surface tension, liquid-liquid wetting, viscosity ratio, and inlet velocity. It is based upon an N-component lattice Boltzmann method with interrupted coalescence [Dupin, Philos. Trans. R. Soc. London, Ser. A 362, 1885 (2004)], here adapted for calculations at low capillary and Reynolds numbers, with wetting and significantly reduced spurious flow. Results over 2 orders of magnitude in Reynolds number are presented.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/PhysRevE.73.055701 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
One-step antifouling coating of polystyrene using engineered polypeptides.
J Colloid Interface Sci
January 2025
Physical Chemistry and Soft Matter, Wageningen University & Research, Stippeneng 4 6708 WE Wageningen, The Netherlands. Electronic address:
Unwanted nonspecific adsorption caused by biomolecules influences the lifetime of biomedical devices and the sensing performance of biosensors. Previously, we have designed B-M-E triblock proteins that rapidly assemble on inorganic surfaces (gold and silica) and render those surfaces antifouling. The B-M-E triblock proteins have a surface-binding domain B, a multimerization domain M and an antifouling domain E.
View Article and Find Full Text PDFAdvancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs.
Drug Metab Pharmacokinet
December 2024
Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.
This study explored the evolving landscape of Microphysiological Systems (MPS), with a focus on organoids and organ-on-a-chip (OoC) technologies, which are promising alternatives to animal testing in drug discovery. MPS technology offers in vitro models with high physiological relevance, simulating organ function for pharmacokinetic studies. Organoids composed of 3D cell aggregates and OoCs mimicking in vivo environments based on microfluidic platforms represent the forefront of MPS.
View Article and Find Full Text PDFMicrofluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions.
Lab Chip
January 2025
Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland.
A novel microfluidic platform was designed to study the cellular architecture of endothelial cells (ECs) in an environment replicating the 3D organization and flow of blood vessels. In particular, the platform was constructed to investigate EC defects in slow-flow venous malformations (VMs) under varying shear stress and flow conditions. The platform featured a standard microtiter plate footprint containing 32 microfluidic units capable of replicating wall shear stress (WSS) in normal veins and enabling precise control of shear stress and flow directionality without the need for complex pumping systems.
View Article and Find Full Text PDFFlow environment affects nutrient transport in soft plant roots.
Soft Matter
January 2025
Microfluidics and Microscale Transport Processes Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India.
This work estimates Michaelis-Menten kinetics parameters for nutrient transport under varying flow rates in the soft roots of Indian mustard () using a plant fluidic device. To find the metallic components within the roots, inductively coupled plasma mass spectrometry (ICP-MS) analysis was performed. The flow rate-dependent metabolic changes were examined using Raman spectral analysis.
View Article and Find Full Text PDFMicrofluidic organ-on-chip systems for periodontal research: advances and future directions.
Front Bioeng Biotechnol
January 2025
Faculty of Dentistry, National University of Singapore, Singapore, Singapore.
Advances in tissue engineering and microfluidic technologies have enabled the development of sophisticated models known as organ-on-a-chip (OoC) or microphysiological systems. These systems enable to potential to simulate the dynamic interactions between host tissues and their microenvironment including microbes, biomaterials, mechanical forces, pharmaceutical, and consumer-care products. These fluidic technologies are increasingly being utilized to investigate host-microbe and host-material interactions in oral health and disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!