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Background: Lip and oral cavity cancer is leading cause of cancer mortality among Indian men. This study evaluated diagnostic accuracy of mobile health (mHealth) enabled screening for early detection of oral premalignant lesions or oral cancer (OPML/OC). It also described epidemiology of tobacco and other substance use and associated oral lesions in rural northern India.
View Article and Find Full Text PDFDownregulation of PAX1 in OSCC Enhances Stemness and Immunosuppression via IFIT1 and PD-L1 Pathways.
Oral Dis
January 2025
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Objective: Our study investigated how arecoline-induced extracellular vesicle (EV) secretion suppresses PAX1 protein production through DNA hypermethylation and examined whether PAX1 downregulation enhances cancer stemness and immunosuppression in the tumor microenvironment.
Materials And Methods: EVs were isolated from SAS/TW2.6 cancer cell lines using ultracentrifugation and identified using transmission electron microscopy.
Hearing Impairment in Oral Submucous Fibrosis: A Systematic Review.
Ear Nose Throat J
January 2025
Department of Dentistry, Zydus Medical College and Hospital, Dahod, Gujarat, India.
Article Synopsis
- Oral submucous fibrosis (OSMF) is a serious condition associated with areca nut chewing, linked to dental health and possibly hearing impairment, prompting a need for investigation into its effects on hearing.
- A systematic review of 1137 articles identified 18 studies showing a significant correlation between OSMF severity and hearing loss, particularly conductive hearing loss in advanced cases.
- The review highlighted that Eustachian tube dysfunction (ETD) often contributes to hearing issues in OSMF patients, emphasizing the importance of multidisciplinary management and early audiological screening for better patient outcomes.
Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity.
Phytochemistry
December 2024
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Engineering Research Center for Modernization of TCM, Jinan University, Guangzhou, 510632, PR China; NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou, 510632, PR China. Electronic address:
Eleven undescribed piperidine alkaloids, arecachines A‒J (1-11), were isolated from the peels of Areca catechu. Compounds 8-11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra.
View Article and Find Full Text PDFPrevalence and Patterns of Polysubstance Use (Tobacco and Other Substances) and Associated Factors: A Cross-Sectional Analysis in a High-Risk Cohort for Oral Cancer in Varanasi, India, with a Special Focus on Young Emerging Adults.
Nicotine Tob Res
December 2024
Professor, Dept of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, India.
Introduction: The dearth of population-based data on polysubstance use, especially in young emerging adults, presents a critical gap in understanding public health challenges, particularly in rural India, where tobacco and oral cancer are prevalent. This study addresses this gap by investigating the prevalence and patterns of substance use, with a focus on young emerging adults (18-29 years) within a high-risk cohort for oral cancer in Varanasi, India.
Methods: The study involved a cross-sectional analysis of baseline data from 10,101 participants within a high-risk cohort in rural settings of the Varanasi district between December 2020-June 2023.
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