Introduction: Numerous treatments have been proposed in patients with keloid scars. Unfortunately, most exhibit poor efficacy. The preliminary results obtained in ten patients with large keloid scars treated by shaving followed by cryosurgery are reported.
Patients And Methods: Ten patients with one or more keloid scars were treated by shaving of the keloid immediately followed by cryosurgery of underlying scar tissue using an impedance of 500 k Ohms. Minimum post-treatment follow-up was 12 months. "Major response" was defined as a reduction in keloid thickness of 80% to 100%, "moderate response" as an improvement of 50% to 80% or partial relapse, and failure as an improvement of less than 50% or complete relapse after treatment.
Results: A total of 16 keloids in ten patients (7 men, 3 women) aged from 10 to 45 years old (mean age: 25 years) were treated. Keloids were localised on the lower lobe of the ear (n=10), on the ear lobe (n=3), on the neck (n=1), on the pubis (n=1), and on the presternal area (n=1). Mean duration of keloids was 3.1 years (18 months - 10 years). Mean follow-up was 23 months (12-56 months). "Major responses" were observed in 13 cases (82%) (3 cases required further treatment); "moderate response" was observed in 3 cases (18%).
Conclusion: These preliminary results are highly encouraging since all patients showed improvement. Shaving associated with cryosurgery appears to us to be a useful treatment for large keloids scars, particularly after otoplastic surgery.
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http://dx.doi.org/10.1016/s0151-9638(06)70884-5 | DOI Listing |
Arch Dermatol Res
January 2025
Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan, China.
The stress response following burns may be a crucial factor in keloid formation, yet the underlying pathological mechanisms remain to be elucidated. This study initially investigated how heat shock factor 1 (HSF1) and heat shock proteins (HSPs) within the heat shock pathway influence keloid fibrosis, providing insights into the role of the heat shock response in keloid development. This study aims to further elucidate the role of the heat shock pathway in keloid fibrosis and investigate the specific function of HSF1 within this pathway.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Some studies have confirmed that pathogens can cause infection through bacterial cultures on the surface of infectious keloids. However, further exploration of the comparison between infectious and non-infectious keloids and the bacterial flora of infectious foci is lacking. To investigate the differential flora of purulent secretions on the surface of infectious keloids compared to non-infectious keloids and to determine the microbial composition within the infectious foci.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Oral and Maxillofacial Surgery, Guiyang Hospital of Stomatology, Guiyang, 550000, China.
The aim of this study was to investigate the effect of dental pulp stem cell-derived exosomes (DPSCs-Exos) on the biological behaviour of fibroblasts, particularly on keloid fibroblasts (KFs) and normal skin fibroblasts (NFs), with a view to providing new insights into cellular regenerative medicine. We obtained DPSCs-Exos by ultracentrifugation and co-cultured it with KFs and NFs. We detected its effect on cell proliferation using the CCK-8 assay; cell migration ability by cell scratch and Transwell assays; extracellular matrix synthesis using the hydroxyproline content assay; the expression levels of genes associated with fibrosis by PCR assay; and the expression levels of proteins related to fibrosis in the cells using the Western Blot method.
View Article and Find Full Text PDFJ Control Release
January 2025
Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address:
Keloids are pathological scars characterized by excessive fibroblast proliferation, abnormal collagen deposition, and chronic inflammation, which often result in high recurrence rates and limited treatment success. Targeting BACH1 with gene therapy has shown promise in regulating fibroblast activity and reducing inflammation. However, effective delivery systems for targeted gene therapy in keloids remain a major challenge.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Dermatology Department, Yanbian University Hospital, 1327 Juzi St, Yanji, 133002, Jilin, China.
Pathological scars are classified into hypertrophic scars and keloids, and currently have poor treatment outcomes and high recurrence rates. Bleomycin has received widespread attention in scar treatment in recent years, but there is currently no exploration on its real-world data. PubMed, Embase, and Cochrane databases were searched, and eight retrospective studies on the use of bleomycin for treatment were included, covering a total of 562 patients with keloids and hypertrophic scars.
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