Background: A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine.
Methods: The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently.
Results: Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed.
Conclusions: The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.
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| http://dx.doi.org/10.1111/j.1365-4632.2006.02751.x | DOI Listing |
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