[Fraud in biomedical literature].

The basic ethical principles in science are internationally recognised in all disciplines of science. The first among these is honesty--both towards oneself and towards others. The betrayal of this principle can be seen as deviant behaviour, which may result in the most serious violation of the high ethical standards of science--scientific fraud. Fraudulent behaviour in biomedical sciences is particularly damaging, since all diagnostic and treatment decisions are based on what is published in medical literature. The betrayers of science undermine, to a great extent, the public trust in science, and may destroy the confidence scientists have in each other as well, which is a grave danger to science itself. In this article, several high profile cases of scientific fraud--involving falsification, fabrication of data, and plagiarism--are described. The damaging effect they had on both science and the scientific community led to the codification of the concept of Good Scientific Practice (GSP)--an international quality standard for designing, conducting, recording, and reporting research. The concept of GSP sets internationally valid benchmarks for quality assurance, and also provides safeguards against scientific dishonesty and fraud.