Background: Involved regions of the skin in patients with atopic dermatitis (AD) have been shown to have higher transepidermal water loss (TEWL), indicating a compromised skin barrier. Whether uninvolved skin also has diminished barrier characteristics is controversial.
Objectives: To study the penetration of sodium lauryl sulphate (SLS) into uninvolved skin of patients with AD compared with the skin of control subjects.
Methods: Percutaneous penetration was assessed using the tape stripping technique on the stratum corneum (SC). Twenty patients with AD and 20 healthy subjects were exposed to 1% SLS for 4 h on the mid-volar forearm. After the end of exposure the SC was removed by adhesive tape. The amount of SLS was determined in each consecutive strip. Fick's second law of diffusion was used to deduce the diffusivity and the partition coefficient of SLS between water and the SC.
Results: The SC thickness was similar in both groups; however, the TEWL was higher in patients with AD compared with that of the control group (mean+/-SD 8.4+/-4.3 and 6.3+/-2.0 g m-2 h-1, respectively). There was a correlation between SC thickness and TEWL in control subjects but no correlation was found in patients with AD. The diffusivity of SLS through uninvolved AD skin was higher compared with normal skin (mean+/-SD 12.7+/-5.8x10(-9) and 6.2+/-3.0x10(-9) cm-2 h-1, respectively), while the partition coefficient between SC and water was lower (mean+/-SD 137+/-64 and 196+/-107, respectively).
Conclusions: The results show a different penetration profile of SLS into the SC of patients with AD compared with control subjects. This indicates that even noninvolved skin in patients with AD has altered barrier characteristics, emphasizing the importance of skin protection and prevention of skin contact with chemicals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2133.2006.07319.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Radiotherapy as a metastasis directed therapy for liver oligometastases - comparative analysis between CT-guided interstitial HDR brachytherapy and two SBRT modalities performed on double-layer and single layer LINACs.
Front Oncol
November 2024
Department of Radiotherapy, Medical University of Lodz, Łódź, Poland.
Introduction: Surgical resection is gold standard for treatment of liver metastasis, locally ablative techniques including computer tomography (CT)-guided interstitial high-dose-rate (HDR) brachytherapy (CT-BRT) and stereotactic body radiotherapy (SBRT) have gained prominence as alternatives, offering comparable outcomes in selected patients. We aim to compare CT-BRT and SBRT - based on dosimetric analysis.
Material And Methods: Patients who underwent CT-BRT for oligometastatic, ≤4cm liver metastases between 2018 and 2024 were eligible.
Achieving Adherence With NCCN Guidelines for Nonmelanoma Skin Cancer Regarding Peripheral and Deep En Face Margin Assessment (PDEMA).
J Natl Compr Canc Netw
November 2024
2Department of Dermatology, Havard Medical School, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA.
Article Synopsis
- - PDEMA, previously known as CCPDMA, allows for complete histologic visualization of tumor margins, which helps in accurately removing cancerous tissue while preserving healthy tissue.
- - It is the preferred treatment method by NCCN for certain skin cancers due to its high cure rates, with Mohs micrographic surgery being the most common PDEMA technique used in the U.S.
- - The article discusses the differences between Mohs and Tubingen PDEMA techniques, emphasizing the importance of collaboration between surgeons and pathologists, and includes a step-by-step Tubingen protocol with visual aids.
Th1 and Th2 cytokine expression in hyperkeratotic chronic hand eczema and the role of Tofacitinib a oral JAK inhibitor.
Arch Dermatol Res
October 2024
Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences and Research Institute and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Article Synopsis
- * A study analyzed tissue samples from 11 patients with difficult-to-treat CHE, finding increased levels of key cytokines (IL-4, TNF-α, IFN-γ) compared to unaffected skin.
- * Tofacitinib was administered to 15 patients, showing promising results with a mean improvement in eczema severity after 4 weeks, although some experienced side effects and relapses after stopping treatment.
Long-term remission of Hailey-Hailey disease by Er:YAG ablative laser therapy.
J Eur Acad Dermatol Venereol
October 2024
Department of Dermatology, Centre of Expertise for Genodermatoses, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Background: Hailey-Hailey disease (HHD) is a rare genetic therapy-resistant blistering disease with great disease burden. Treatment is currently focused on symptomatic relief. Er:YAG ablative laser therapy is a therapeutic modality with promising results, though evidence is currently scarce.
View Article and Find Full Text PDFProfiling Long Noncoding RNA in Psoriatic Skin Using Single-Cell RNA Sequencing.
J Invest Dermatol
September 2024
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:
The expressions of long noncoding RNAs (lncRNAs) and their roles in epidermal differentiation have been previously defined using bulk RNA sequencing. Despite their tissue-specific expression profiles, most lncRNAs are not well-annotated at the single-cell level. In this study, we evaluated the use of single-cell RNA sequencing to profile and characterize lncRNAs using data from 6 patients with psoriasis with paired uninvolved and lesional psoriatic skin.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!