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Through Space π-Electrons Communication in [2,2]-Paracyclophanes: Unprecendented Stabilization of Radicals.
Angew Chem Int Ed Engl
December 2024
Institut Chimie radicalaire ICR-UMR 7273, Facult� de Saint jerome, avenue Escadrille-Normandie-Niemen, service 562, 13397, Marseille, FRANCE.
Efforts to understand radical stability have led to considerable progress in radical chemistry. In this article, we investigated a novel approach to enhancing the radical stability of carbon-centered radicals through space electron delocalization within [2,2]-paracyclophanes. Alkoxyamines possessing a paracyclophane scaffold exploit face-to-face π-π-interactions between the aromatic rings to effectively lower bond dissociation energy (BDE) for NO-C bond homolysis.
View Article and Find Full Text PDFSelf-assembly, cytocompatibility, and interactions of desmopressin with sodium polystyrene sulfonate.
Soft Matter
December 2024
Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04062-000, Brazil.
Peptide-polymer systems hold strong potential for applications in nanotherapeutics. Desmopressin, a synthetic analogue of the antidiuretic hormone arginine vasopressin, may serve as a valuable case of study in this context since it is a first-line treatment for disorders affecting water homeostasis, including diabetes insipidus. It also has an established use as a hemostatic agent in von Willebrand disease, and recently, its repurposing has been suggested as a neoadjuvant in the treatment of certain types of cancer.
View Article and Find Full Text PDFBreast Cancer-Related Chemical Exposures in Firefighters.
Toxics
September 2024
Silent Spring Institute, Newton, MA 02460, USA.
To fill a research gap on firefighter exposures and breast cancer risk, and guide exposure reduction, we aimed to identify firefighter occupational exposures linked to breast cancer. We conducted a systematic search and review to identify firefighter chemical exposures and then identified the subset that was associated with breast cancer. To do this, we compared the firefighter exposures with chemicals that have been shown to increase breast cancer risk in epidemiological studies or increase mammary gland tumors in experimental toxicology studies.
View Article and Find Full Text PDFMaternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus.
J Nanobiotechnology
October 2024
Military Medical Sciences Academy, Academy of Military Sciences, Tianjin, 300050, China.
Article Synopsis
- - Concerns are rising about polystyrene nanoplastics (PS-NPs) impacting human health, particularly concerning their transfer from mothers to offspring, which can lead to cognitive deficits.
- - A study involved administering PS-NPs to pregnant and nursing female rats to examine the neurotoxic effects and behavioral changes in their offspring, focusing on mechanisms like ferroptosis in the hippocampus.
- - Findings indicate that low doses of PS-NPs can induce cognitive decline in offspring by triggering ferroptosis through oxidative stress and affecting key antioxidant levels, highlighting the potential risks of nanoplastics during critical developmental periods.
Detection of Tn-antigen in breast and prostate cancer models by VVL-labeled red dye-doped nanoparticles.
Nanomedicine (Lond)
October 2024
Institute of Biomedicine, University of Turku, Turku, 20520, Finland.
Fluorescence detection of breast and prostate cancer cells expressing Tn-antigen, a tumor marker, with lectin (VVL)-labeled nanoparticles. Breast and prostate cancer cells engineered to express high levels of Tn-antigen and non-engineered controls were incubated with VVL-labeled or unlabeled red dye-doped silica-coated polystyrene nanoparticles. The binding to cells was studied with flow cytometry, confocal microscopy, and electron microscopy.
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