Medial collateral ligament (MCL) injury is one of the most common knee injuries, especially in young athletic patients. Most MCL injuries can be managed conservatively with good results. However, a complete understanding of knee anatomy and the involved structures is necessary to make intelligent treatment decisions. We will review the anatomy and biomechanics of the MCL, classification systems for MCL injuries, and operative and nonoperative treatment for acute and chronic MCL injuries.
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Mil Med
January 2025
Musculoskeletal Department, Naval Health Clinic Annapolis/United States Naval Academy, Annapolis, MD 21402, USA.
Introduction: Acute anterior cruciate ligament (ACL) injuries can be disabling because of prolonged rehabilitation process following surgical reconstructions. Rates of ACL injuries among military service members are close to 10 times greater than the general civilian population, likely because of the operation tempo and the unique physical requirements. Studies debated functional testing requirements for return to sports, but no study investigated the impact of functional training and re-injury rates following ACL reconstruction and their association with functional testing outcomes and time to return to full duty in United States Naval Academy (USNA) Midshipmen.
View Article and Find Full Text PDFAm J Sports Med
January 2025
North Sydney Orthopaedic and Sports Medicine Centre, Wollstonecraft, New South Wales, Australia.
Background: A growing body of evidence surrounds secondary meniscal and cartilage pathology after delay to anterior cruciate ligament (ACL) reconstruction (ACLR). Many of these studies focus on or include an adult population.
Purpose: To elucidate the prevalence of secondary meniscal and chondral pathology with delay to ACLR in the adolescent population as well as examine the influence of sex, skeletal maturity, and trends over the years.
CNS Neurosci Ther
January 2025
Department of Neurology, School of Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Objective: This study aims to investigate how the E3 ubiquitin ligase LITAF influences mitochondrial autophagy by modulating MCL-1 ubiquitination, and its role in the development of epilepsy.
Methods: Employing single-cell RNA sequencing (scRNA-seq) to analyze brain tissue from epilepsy patients, along with high-throughput transcriptomics, we identified changes in gene expression. This was complemented by in vivo and in vitro experiments, including protein-protein interaction (PPI) network analysis, western blotting, and behavioral assessments in mouse models.
Arthroscopy
December 2024
Orthopaedic Surgery Department - Aker, Oslo University Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Oslo Sports trauma research Center, Norwegian School of Sports Sciences, Oslo, Norway. Electronic address:
Background: The co-occurrence of anterior cruciate ligament (ACL) rupture with medial collateral ligament (MCL) rupture is a compound injury that can be associated with meniscal tears.
Purpose: To report the characteristics of meniscal tears in knees with isolated ACL versus combined ACL and MCL injuries, analyzing their frequency, distribution by site, and lesion type.
Study Design: Cross-sectional study; Level of evidence, 3.
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