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Solitary extramedullary plasmacytoma in the hilar region: A case of minimal marrow involvement in an elderly male.
Int J Surg Case Rep
December 2024
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:
Introduction And Importance: Solitary extramedullary plasmacytoma (SEP) is a rare plasma cell neoplasm, constituting around 3 % of plasma cell malignancies. SEP typically presents as a single tumor, either in bone or soft tissue, without systemic disease, and is often misdiagnosed due to its nonspecific symptoms. Diagnosis requires biopsy and extensive imaging studies to exclude multiple myeloma and other malignancies.
View Article and Find Full Text PDFA lymph node lesion of hyper IL-6 syndrome mimicking plasmacytoma, IgG4-related disease, and Castleman disease.
J Clin Exp Hematop
December 2024
Division of Pathology and Laboratory Medicine, JA Suzuka General Hospital, Suzuka, Mie, Japan.
A 72-year-old male patient presented fatigue, anemia, elevated total protein, IgG, IgG4, IL-6, and vascular endothelial growth factor (VEGF) levels. Initial diagnostics suspected multiple myeloma. A plane computed tomography (CT) scan showed pneumonia and the enlargement of generalized lymph nodes.
View Article and Find Full Text PDFIntegration of clinical outcomes and molecular features in extramedullary disease in multiple myeloma.
Blood Cancer J
December 2024
Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Multiple myeloma (MM) remains incurable despite novel therapeutics. A major contributor to the development of relapsed/refractory and resistant MM is extraosseous extramedullary disease (EMD), whose molecular biology is still not fully understood. We analyzed 528 MM patients who presented to our institution between 2014 and 2021 and who had undergone molecular testing.
View Article and Find Full Text PDFPrimary pulmonary plasmacytoma: A case report.
Medicine (Baltimore)
December 2024
Department of Respiratory and Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Article Synopsis
- Extramedullary plasmacytoma is a rare malignant tumor found in tissues outside of bone marrow, with primary pulmonary plasmacytoma (PPP) being particularly uncommon and diagnosed through biopsy.
- A 65-year-old woman experienced chronic cough and was hospitalized with acute chest pain, where imaging revealed extensive lung inflammation.
- The diagnosis was confirmed via bronchoscopy, leading to hormone anti-inflammatory treatment; however, the patient was lost to follow-up, emphasizing the need for awareness and biopsy in similar cases to ensure proper diagnosis and management of PPP.
Role of Imaging in Multiple Myeloma: A Potential Opportunity for Quantitative Imaging and Radiomics?
Cancers (Basel)
December 2024
Radiological Diagnostics Center, The National Institute of Medicine of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.
Multiple myeloma (MM) is the second most prevalent hematologic malignancy, particularly affecting the elderly. The disease often begins with a premalignant phase known as monoclonal gammopathy of undetermined significance (MGUS), solitary plasmacytoma (SP) and smoldering multiple myeloma (SMM). Multiple imaging modalities are employed throughout the disease continuum to assess bone lesions, prevent complications, detect intra- and extramedullary disease, and evaluate the risk of neurological complications.
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