AI Article Synopsis
Article Abstract
A series of N-biarylalkyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-ones were prepared and evaluated for biological activity at opioid (mu, delta, kappa) and opioid receptor like-1 (ORL-1) G-protein coupled receptors. Substitution on the biaryl moiety produced enhanced affinity for the mu-opioid receptor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/157340605774598207 | DOI Listing |
Publication Analysis
Top Keywords
opioid receptor
8
8-heteroarylphenalkyl-1-phenyl-138-triazaspiro[45]decan-4-ones opioid
4
receptor modulators
4
modulators series
4
series n-biarylalkyl-1-phenyl-138-triazaspiro[45]decan-4-ones
4
n-biarylalkyl-1-phenyl-138-triazaspiro[45]decan-4-ones prepared
4
prepared evaluated
4
evaluated biological
4
biological activity
4
activity opioid
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!