AI Article Synopsis
- The study aimed to evaluate the effectiveness of low-dose hCG in a GnRH antagonist treatment protocol for women under 40 years old with limited previous IVF cycles.
- A total of 192 women were divided into three groups: one using a GnRH agonist long protocol, another using GnRH antagonist without low-dose hCG, and the third using GnRH antagonist with low-dose hCG.
- Results indicated that the low-dose hCG group had better outcomes in terms of oocyte maturation and embryo quality, while also reducing the risk of ovarian hyperstimulation syndrome, although pregnancy rates were similar across all groups.
Article Abstract
Purpose: To examine the efficacy of low-dose hCG using a GnRH antagonist protocol.
Methods: Prospective randomized study was performed at the Kyono Ladies Clinic. One hundred ninety-two women (<40 -years old, <3 previous cycles) were randomly assigned to GnRH agonist (buserelin) long protocol (LP, n = 66), GnRH antagonist (cetrorelix) with no low-dose hCG protocol (NhCGP, n = 63), or GnRH antagonist with low-dose hCG protocol (hCGP, n = 63).
Results: The hCGP was associated with reduced total amounts of FSH, increased oocyte maturation rate, high-quality day 3 embryos rate, and number of frozen embryos. Ovarian hyperstimulation syndrome (OHSS) tended to be lower in the GnRH antagonist protocol. Pregnancy and implantation rates did not differ significantly between study groups.
Conclusions: Daily low-dose hCG supplementation in the late follicular phase could improve the outcome in FSH based-GnRH antagonist protocol. This protocol, however, does require further modifications, including determination of the optimal doses for hCG and gonadotropin pretreatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454910 | PMC |
| http://dx.doi.org/10.1007/s10815-006-9036-2 | DOI Listing |
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