AI Article Synopsis
- - A cis-isomer of a C(8)-diol ester of okadaic acid was discovered while purifying pectenotoxins from Dinophysis acuta in New Zealand.
- - This compound is the first known cis-isomer of an okadaic acid C(8)-diol-ester found in this alga, identified through NMR and LC-MS techniques.
- - The more common trans-C(8)-diol ester was also isolated and found to quickly convert to okadaic acid when exposed to supernatant from green-lipped mussel hepatopancreas.
Article Abstract
A cis-isomer of a C(8)-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C(8)-diol-ester identified in Dinophysis. The more abundant trans-C(8)-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.
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| http://dx.doi.org/10.1016/j.toxicon.2006.04.018 | DOI Listing |
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