Heat shock protein (Hsp)90 is a chaperone with essential roles in maintaining transformation and in elevating the survival and growth potential of cancer cells. The recognition of Hsp90 as an important target in cancer therapy has prompted the identification, development and clinical translation of a large array of Hsp90 inhibitors. This review discusses the modalities that may interfere with this chaperone's function and describes the status of existing and emerging Hsp90 inhibitor classes.
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Core transcriptome network modulates temperature (heat and cold) and osmotic (drought, salinity, and waterlogging) stress responses in oil palm.
Front Plant Sci
December 2024
SD Guthrie Research Sdn. Bhd., Banting, Selangor Darul Ehsan, Malaysia.
Oil palm () yield is impacted by abiotic stresses, leading to significant economic losses. To understand the core abiotic stress transcriptome (CAST) of oil palm, we performed RNA-Seq analyses of oil palm leaves subjected to drought, salinity, waterlogging, heat, and cold stresses. A total of 19,834 differentially expressed genes (DEGs) were identified.
View Article and Find Full Text PDFThe cellular stress response (CSR) is a conserved mechanism that protects cells from environmental and physiological stressors. The heat shock response (HSR), a critical component of the CSR, utilizes molecular chaperones to mitigate proteotoxic stress caused by elevated temperatures. We hypothesized that while the canonical HSR pathways are conserved across cell types, specific cell lines may exhibit unique transcriptional responses to heat shock.
View Article and Find Full Text PDFDifferential physiological and yield responses of selected mung bean (Vigna radiata (L.) R. Wilczek) genotypes to various high-temperature stress regimes.
Sci Rep
January 2025
Feed the Future Innovation Lab for Collaborative Research on Sustainable Intensification, Kansas State University, Manhattan, KS, 66506, USA.
The increasing frequency of heat stress events due to climate change disrupts all stages of plant growth, significantly reducing yields, especially in crops like mung bean (Vigna radiata (L.) R. Wilczek).
View Article and Find Full Text PDFCooperative condensation of RNA-DIRECTED DNA METHYLATION 16 splicing isoforms enhances heat tolerance in Arabidopsis.
Nat Commun
January 2025
The National Engineering Laboratory of Crop Stress Resistance Breeding, School of Life Sciences, Anhui Agricultural University, Hefei, China.
Dissecting the mechanisms underlying heat tolerance is important for understanding how plants acclimate to heat stress. Here, we identify a heat-responsive gene in Arabidopsis thaliana, RNA-DIRECTED DNA METHYLATION 16 (RDM16), which encodes a pre-mRNA splicing factor. Knockout mutants of RDM16 are hypersensitive to heat stress, which is associated with impaired splicing of the mRNAs of 18 out of 20 HEAT SHOCK TRANSCRIPTION FACTOR (HSF) genes.
View Article and Find Full Text PDFEffects of thermopriming and bacteria-mediated heat-stress acclimation strategies on seed yield and quality criteria in Brassica napus cv Aviso and Camelina sativa cv Calena.
Planta
January 2025
Normandie Université, UNICAEN, INRAE, UMR 950 Ecophysiologie Végétale, Agronomie Et Nutritions N, C, S, Esplanade de La Paix CS14032, 14032, Caen Cedex 5, France.
The effects of intense heat during the reproductive phase of two Brassica species-B. napus and C. sativa-could be alleviated by a prior gradual increase exposure and/or PGPR inoculation.
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