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Optimizing VGG16 deep learning model with enhanced hunger games search for logo classification.
Sci Rep
December 2024
Department of Computer Science, Birzeit University, P.O. Box 14, Birzeit, West Bank, Palestine.
Accurate classification of logos is a challenging task in image recognition due to variations in logo size, orientation, and background complexity. Deep learning models, such as VGG16, have demonstrated promising results in handling such tasks. However, their performance is highly dependent on optimal hyperparameter settings, whose fine-tuning is both labor-intensive and time-consuming.
View Article and Find Full Text PDFEstablishing clinical research networks for future infectious disease outbreak responses in Southeast Asia: Report of a workshop on challenges and opportunities.
IJID Reg
March 2025
Programme for Research in Epidemic Preparedness and Response (PREPARE), Ministry of Health, Singapore.
The COVID-19 pandemic highlighted the critical need for well-established clinical research networks capable of rapid response during infectious disease outbreaks. In Southeast Asia, the absence of active research networks at the onset of the COVID-19 contributed to gaps in regional preparedness. This manuscript discusses the challenges and opportunities identified during a regional workshop held in Singapore (February 26 to March 1, 2024), which brought together 130 stakeholders from across the region.
View Article and Find Full Text PDFWhat are clinically significant anti-drug antibodies and why is it important to identify them.
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translational Pharmacokinetics Pharmacodynamics (tPKPD), Genentech Inc., San Francisco, CA, United States.
The FDA has released new draft guidance to standardize how immunogenicity of protein therapeutics is described in product labels. A key aspect to this new guidance is that companies should describe anti-drug antibodies that have clinical significance in addition to reporting ADAs' incidence. Factors to consider when determining clinical significance include if those antibodies have a significant effect on the drug's pharmacokinetics, pharmacodynamics, efficacy, and/or safety.
View Article and Find Full Text PDFDetermining influences of intraoperative s-ketamine on postoperative delirium and cognitive function: methodology is important.
J Cardiothorac Surg
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Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, No. 134 Dongjie, Fuzhou, 350001, China.
The letter to the editor was written in response to the recent article by Wang et al. "The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery", which is published in Journal of Cardiothoracic Surgery. 2024; 19(1):324.
View Article and Find Full Text PDFIntensified conditioning containing decitabine versus standard myeloablative conditioning for adult patients with KMT2A-rearranged leukemia: a multicenter retrospective study.
BMC Med
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Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended for patients with KMT2A-rearranged (KMT2A-r) leukemia whereas relapse remains high. We aimed to determine whether intensified conditioning containing decitabine (Dec) could reduce relapse compared with standard myeloablative conditioning in adult patients with KMT2A-r leukemia.
Methods: We performed a multicenter retrospective study at seven institutions in China.
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