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Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study.
Antimicrob Agents Chemother
December 2024
University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
This study aimed to describe the population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and to identify dosing regimens with a high likelihood of achieving effective exposures. Serial blood samples were collected over a single-dosing interval during ECMO. Total plasma concentrations were measured by a validated chromatographic assay.
View Article and Find Full Text PDFEffect of Epidural Volume Extension Using Low-Dose Sufentanil Combined with Low-Concentration Ropivacaine on Visceral Pain During Cesarean Sections: A Randomized Trial.
Pain Physician
December 2024
Department of Anesthesia, Jiaxing University Affiliated Women and Children Hospital, Jiaxing, China.
Background: Visceral pain is common in cesarean sections conducted under combined spinal-epidural anesthesia (CSE). Epidural volume extension (EVE) is a technique for enhancing the effect of intrathecal blocks by inducing epidural fluid boluses in the CSE. Whether EVE that uses different drugs can reduce visceral pain during cesarean sections is rarely studied.
View Article and Find Full Text PDFThe impact of dual-enrolee (Medicare/Medicaid) status on venous leg ulcer outcomes: a retrospective study.
J Wound Care
December 2024
Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Hempstead, NY, US.
Article Synopsis
- The study aimed to analyze the impact of race, sex, comorbidities, and Medicaid status on health outcomes for patients with hard-to-heal venous leg ulcers (VLUs), comparing Medicare-only beneficiaries to Medicare/Medicaid dual-enrollees from October 2015 to October 2019.
- Using Medicare claims data, the research focused on treatment methods, demographic comparisons, and quantified outcomes like ulcer closure time and quality of life metrics, finding notable differences between the two groups.
- Results showed that dual-enrollees had a higher burden of comorbidities, greater representation from minority backgrounds, and significantly increased rates of emergency visits and cellulitis compared to Medicare-only enrollees, with early use of certain
Hyperbaric Oxygen Therapy for Veterans With Combat-Associated Posttraumatic Stress Disorder: A Randomized, Sham-Controlled Clinical Trial.
J Clin Psychiatry
November 2024
Sagol Center for Hyperbaric Medicine and Research, Shamir Medical Center, Zerifin, Israel.
Cumulative data indicate that new protocols of hyperbaric oxygen therapy (HBOT) may induce neuroplasticity and improve clinical symptoms of patients suffering from posttraumatic stress disorder (PTSD). The aim of the current study was to evaluate the effects of HBOT on veterans with combat-associated PTSD (CA-PTSD) in a randomized, sham-controlled trial. Male veterans aged 25-60 years with CA-PTSD, with a Clinician-Administered PTSD Scale for (CAPS-5) score above 20, were included.
View Article and Find Full Text PDFA nursing-led sepsis response team guiding resuscitation with point-of-care ultrasound: A review and model for improving bundle compliance while individualizing sepsis care.
SAGE Open Med
November 2024
Department of Emergency Medicine, Riverside University Health System Medical Center, Moreno Valley, CA, USA.
A dysregulated host response to infection resulting in life-threatening organ dysfunction defines the onset of sepsis. Unfortunately, sepsis is common, costly, and deadly. The Surviving Sepsis Campaign publishes regularly updated, evidence-informed, detection, and treatment guidelines culminating in time-sensitive care "bundles.
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