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Rational design and therapeutic potential of MyD88 inhibitory peptide in psoriasis.
Biomed Pharmacother
January 2025
Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea; S&K Therapeutics, Ajou University Campus Plaza 418, Worldcup-ro 199, Yeongton-gu, Suwon 16502, Republic of Korea. Electronic address:
Myeloid differentiation primary-response 88 (MyD88) is a crucial adaptor protein for initiating immune responses via Toll-like receptors (TLRs). This study employed a rational peptide design approach to develop MyD88 inhibitory peptides targeting the MyD88 interaction interface. The designed peptide, MyDIP2-4, was evaluated for its efficacy in inhibiting MyD88-dependent signaling in human and mouse cell lines.
View Article and Find Full Text PDFLow-dose radiation ameliorates PM2.5-induced lung injury through non-canonical TLR1/TLR2-like receptor pathways modulated by Akkermansia muciniphila.
Ecotoxicol Environ Saf
January 2025
NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China. Electronic address:
Exposure of PM2.5 can cause different degrees of lung injury, which is referred with inflammatory response. Some evidences showed that low-dose radiation (LDR) induces hormesis in immune, however, it is unknown if LDR ameliorates the PM2.
View Article and Find Full Text PDFPeptide-based vaccine design against Hendra virus through immunoinformatics approach.
Vet Immunol Immunopathol
December 2024
Department of Biochemistry, Bahauddin Zakariya University, Multan 66000, Pakistan. Electronic address:
The Hendra virus (HeV) has resulted in epidemics of respiratory and neurological illnesses in animals. Humans have contracted diseases with high fatality rates as a result of infected domestic animals, but effective vaccinations and therapies are currently not available against HeV. Herein, we analyzed the proteome of HeV and constructed an effective and innovative multi-epitope vaccine using immunoinformatics techniques.
View Article and Find Full Text PDFBeyond the Toll-like receptor 4. Structure-dependent Lipopolysaccharide Recognition Systems: How far are we?
ChemMedChem
January 2025
University of Naples Federico II, Chemical Sciences, via cinthia 4, 80126, Naples, ITALY.
Article Synopsis
- Lipopolysaccharides (LPSs) are crucial molecules in immunology and vaccinology, extensively studied for their significant impact across various scientific fields.
- Research predominantly focuses on the activation of the immune response through the MD-2/TLR4 complex, which is the primary known pathway for LPS sensing.
- This review examines other LPS recognition systems and their interconnected signaling pathways, emphasizing their importance in maintaining health and their roles in severe diseases, which could lead to new treatments for immune-related conditions.
Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review.
Front Immunol
January 2025
Department of Pediatrics, West China Second University Hospital of Sichuan University, Chengdu, China.
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disease. Recently, an increasing number of studies have shown that Toll-like receptor 4 (TLR4), widely distributed on the surface of a variety of epithelial cells (ECs) and immune sentinel cells in the gut, plays a vital role in developing IBS.
Objectives: We sought to synthesize the existing literature on TLR4 in IBS and inform further study.
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