Regulation and clinical significance of urokinase-receptor (u-PAR), an invasion-related molecule.

This review focuses on the urokinase-receptor (u-PAR), one of the critical molecules mediating tumor-associated proteolysis, invasion, and metastasis, amongst other phenomena associated with tumor progression. Especially, the article gives an overview on the molecular regulation of u-PAR, and its potential clinical and therapeutic relevance in gastrointestinal cancers.