Treatment of clinical laminitis usually fails to prevent some degree of persistent disability; thus, intervention should aim at avoiding risk factors and preventing the disease. Efficiency of intervention would be improved by identifying predisposed horses and ponies. A herd of 160 healthy ponies included 54 previously laminitic (PL) and 106 never laminitic (NL). Pedigree analysis was consistent with dominant inheritance partially suppressed in males. Blood analysis revealed higher plasma concentrations of insulin and triglycerides but not cortisol, glucose, or free fatty acids in the PL group. Proxies for insulin sensitivity and beta-cell responsiveness, which were calculated from plasma insulin and glucose, indicated compensated insulin resistance in the PL group. A prelaminitic metabolic syndrome (PLMS) was derived statistically to have cut-off points for the 2 proxies, hypertriglyceridemia, and body condition score. It had a total predictive power of 78%. It identified 62 ponies with PLMS, and 98 as PLMS-free. Two months later, pasture starch concentration doubled, and 13 clinical cases of laminitis developed, 11 in the PLMS group and 2 in the PLMS-free group, giving an odds ratio of 10.4 (P = 0.0006). The PLMS can be used to identify predisposed ponies in need of special care; the efficiency of intervention would increase nearly 3-fold in the present case. It enables the design of new interventions suitable for testing. The PLMS also might influence market values.
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http://dx.doi.org/10.1093/jn/136.7.2090S | DOI Listing |
Acta Biomater
March 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
Traditional methods of plasmid delivery, including viral vectors, lipofection, and electroporation, are widely used for gene editing but have limitations, such as cellular toxicity, limited transfection efficiency in primary cells, and nonspecific side effects. Here, we report the development of nucleus pulposus cell (NPC)-mimicking nanoparticles (HIF1A@NNP) with an NPC membrane as the shell and pcDNA3.1-rHIF1A encapsulated in the core via extrusion.
View Article and Find Full Text PDFJ Prosthet Dent
March 2025
Associate Professor, Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address:
Statement Of Problem: The precision and accuracy of intraoral scanners for complete arch implant scanning is questionable as it is affected by the absence of anatomic features, the presence of large homogenous areas, and the lack of clear reference points, all of which create inherent errors in the image stitching process by the scanner software program.
Purpose: The purpose of this in vitro study was to test a newly designed scan-aid apparatus for evaluating the effect of geometric heterogeneity and additional reference points on the time efficiency and scanning precision of complete arch implant scanning.
Material And Methods: A total of 60 scans (20 per group) were performed using an intraoral scanner in 3 different clinical simulations: 2 parallel implants, 4 parallel implants, and 4 implants; 2 anterior implants in parallel axial orientation; and 2 distal implants with a 30-degree posterior inclination.
Anal Chem
March 2025
Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Exosomes have emerged as vital biomarkers for cancer diagnosis because they carry diverse biomolecules, reflecting the physiological state of their original cells. However, despite this potential, there are still challenges in developing highly sensitive, rapid, and efficient detection methods in clinical diagnosis. Here, we present a straightforward approach for the efficient enrichment and SERS quantification of exosomes via the interaction between titanium dioxide (TiO) and the phospholipid bilayer on the exosome membrane.
View Article and Find Full Text PDFFood Microbiol
August 2025
Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China. Electronic address:
The construction of synthetic microbial communities is a crucial strategy for improving the stability of microbial populations and the quality of fermented foods. Jiuyao, an essential saccharification and fermentation starter in Huangjiu production, was the focus of this study. Using metagenomics combined with culture-dependent methods, we identified 11 microbial species involved in Huangjiu fermentation.
View Article and Find Full Text PDFFood Res Int
April 2025
Department of Food Technology, Federal University of Viçosa, Peter Henry Rolfs Avenue, 36570-900 Viçosa, MG, Brazil. Electronic address:
Although virtual reality (VR) holds great potential in sensory research, further investigations are needed to assess the impact of immersion on consumer evaluations. Previous studies have limitations, such as a small number of evaluators, inconsistent graphical quality of virtual environments, lack of comparisons with traditional laboratory settings, and insufficient data on consumer engagement during virtual assessments. To address these gaps, this study evaluated consumer engagement using a presence scale, along with acceptance and emotions evoked during the consumption of an industrial beer (American Lager).
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