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Hemolytic disease of the fetus and newborn and Rhesus alloimmunization in Latin American countries: a scoping review.
BMC Pregnancy Childbirth
December 2024
Immunology LATAM, Janssen, Mendoza, Buenos Aires, CP (1428), 1259, Argentina.
Background: Hemolytic disease of the fetus and newborn (HDFN) is a condition due to maternal blood group antibodies targeting antigens in fetal red blood cells, with significant prenatal/perinatal morbidity and mortality. Severe HDFN cases are often associated with alloimmunization against Rhesus D (RhD) or Kell antigens. Information about HDFN epidemiology and treatment in Latin American countries is limited.
View Article and Find Full Text PDFOnasemnogene Abeparvovec is Safe in Hemolytic Disease of the Newborn: A Case Report.
Neuropediatrics
December 2024
Department of Physiotherapy, King Fahd Specialist Hospital, Dammam, Saudi Arabia.
Spinal muscular atrophy (SMA) is a rare autosomal recessive genetic disease caused by Survival Motor Protein 1 () gene mutations. Classically divided into three types, SMA is characterized by hypotonia, weakness, and tongue fasciculation in the first 6 months of life in type 1, inability to walk and limb weakness in type 2, and failure to run with proximal weakness in type 3 SMA. With the advent of newborn screening, treating presymptomatic patients with Onasemnogene abeparvovec (OA) is the treatment of choice in some centers worldwide.
View Article and Find Full Text PDFBiphasic Behavior of Anti-M Antibody and Hemolytic Disease of the Fetus and Newborn (HDFN).
Cureus
November 2024
Pathology and Laboratory Medicine, University of South Alabama College of Medicine, Mobile, USA.
The anti-M antibody is a cold, naturally occurring immunoglobulin M (IgM) antibody that is generally considered clinically insignificant and often overlooked in transfusion practices and assessments of patients at risk for hemolytic disease of the fetus and newborn (HDFN). However, the presence of an IgG component in this case renders the antibody clinically significant, underscoring the necessity for proper serologic testing during prenatal evaluations. We present a case involving an anti-M antibody with an IgG component to highlight the critical importance of thorough serologic testing during prenatal testing.
View Article and Find Full Text PDFDynamics of antibody engagement of red blood cells and .
Front Immunol
December 2024
Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Exposure to allogenic red blood cells (RBCs), either through pregnancy or transfusion, can result in alloimmunization, which can lead to severe hemolytic transfusion reactions and pregnancy complications. Passively administered antibodies can be used to prevent alloimmunization, where steric hindrance of allogeneic epitopes has been postulated as one mechanism whereby antibody engagement may prevent RBC alloimmunization. However, the dynamics of antibody engagement on the RBC surface has remained difficult to study.
View Article and Find Full Text PDFErythrocyte Alloimmunization and Autoimmunization in the Pediatric Population: A Multicenter, Cross-Sectional Study in Central China.
Transfus Med Hemother
December 2024
Department of Blood Transfusion, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Background: Erythrocyte alloantibodies and autoantibodies complicate transfusion. However, the prevalence of erythrocyte alloimmunization and autoimmunization has not been estimated in the Chinese pediatric population. Therefore, we investigated the prevalence of erythrocyte alloimmunization and autoimmunization in the Chinese pediatric population with the aim of developing a reasonable transfusion management policy in children from China.
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