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Emerging Psychotropic Drug for the Treatment of Trigeminal Pain: Salvinorin A.
Pharmaceuticals (Basel)
November 2024
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Trigeminal neuralgia (TN) is chronic pain caused by damage to the somatosensorial system on the trigeminal nerve or its branches, which involves peripheral and central dysfunction pain pathways. Trigeminal pain triggers disruptive pain in regions of the face, including within and around the mouth. Besides clinical experiences, translating the language of suffering into scientific terminology presents substantial challenges.
View Article and Find Full Text PDFAgomelatine as Antidepressant Treatment in Elderly Patients With Previous Hyponatremia Due To SSRI Use: Case Series.
Hum Psychopharmacol
January 2025
Departamento de Psiquiatría, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Objective: To evaluate agomelatine treatment in elderly patients with major depressive disorder (MDD) who developed hyponatremia while using selective serotonin receptor inhibitors (SSRIs).
Methods: Patients (60 years or older) with hyponatremia after SSRI treatment for MDD were changed to agomelatine 50 mg/day during one month to observe sodium levels during the treatment and change in depressive symptoms. Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression Scale (CGI) of severity were used before and after treatment with agomelatine.
Comparison of the Incidence and Magnitude of Hyponatremia Among Patients With Poststroke Depression Receiving Either Escitalopram or Sertraline.
Pharmacol Res Perspect
December 2024
Clinical Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Article Synopsis
- - Depression is common among stroke survivors, and SSRIs like escitalopram and sertraline are often prescribed, but they can cause low sodium levels (hyponatremia), which may worsen patient outcomes.
- - This study reviewed hospital records from 401 patients over five years to compare the incidence and severity of hyponatremia in those treated with either escitalopram or sertraline.
- - Results showed that both medications were linked to an increased risk of mild hyponatremia, with no significant differences in outcomes between the two drugs, highlighting the need for caution when prescribing these SSRIs.
Psychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016.
Ann Gen Psychiatry
November 2024
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany.
Background: Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients (i.
View Article and Find Full Text PDFOxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials.
JAMA Netw Open
November 2024
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.
Article Synopsis
- MDMA (ecstasy) is being studied as a treatment for PTSD but has the risk of causing low sodium levels (hyponatremia) after just one dose due to factors like vasopressin release and excessive drinking.
- This study aimed to analyze how often and severely hyponatremia occurs after a single MDMA dose, looking at underlying hormonal mechanisms and whether limiting fluid intake could reduce this risk.
- Out of 96 participants, about 31% experienced hyponatremia, but none in the group with fluid restrictions, suggesting that managing fluid intake could lessen the chance of developing this complication.
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