We document the sequelae of the inadvertent introduction of glutaraldehyde into the peritoneal cavity. It describes the clinical course, progressive histological changes to the bowel at different periods over the course of 1 year, and what long-term morbidity remains. The chemical structure, effects, and pathogenesis of glutaraldehyde are described as well as suggestions for avoiding similar problems in the future.
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Three case reports of glutaraldehyde-induced chemical colitis.
Am J Transl Res
May 2023
Department of Gastroenterology, Songyang County People's Hospital No. 21 East Changsong Road, Lishui 323400, Zhejiang, China.
Currently, chemical colitis in clinical practice is mainly caused by iatrogenic factors. The disinfectant glutaraldehyde is one of the common drugs that can cause chemical colitis, but there are few reports about it. From August 2019 to August 2022, 1457 cases of colonoscopy were performed in the endoscopy room of the Second Affiliated Hospital of Zhejiang University School of Medicine and Songyang County People's Hospital, and 3 cases of chemical colitis caused by glutaraldehyde residue are discussed in this report.
View Article and Find Full Text PDFGlutaraldehyde-induced bowel injury during gynecologic laparoscopy.
J Minim Invasive Gynecol
May 2013
Adana Numune Research and Education Hospital, Department of Gynecology and Obstetrics, Adana, Turkey.
Glutaraldehyde is a widely used disinfectant, especially in developing countries, for rapid and effective disinfection of laparoscopic instruments that are not suitable for sterilization in an autoclave. This incident report demonstrates that even remarkably small residual amounts of glutaraldehyde on inadequately cleaned laparoscopic instruments can cause chemical burns during laparoscopic surgery. Our goal is to raise awareness of the possible hazardous effects of glutaraldehyde when necessary measures are not taken to properly sterilize laparoscopic instruments.
View Article and Find Full Text PDFGlutaraldehyde-induced colitis: case reports and literature review.
Kaohsiung J Med Sci
December 2011
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Glutaraldehyde-induced colitis is an uncommon colitis in clinical practice. Because the involvement of colonic segment is determined by the endoscopic part where glutaraldehyde remains, a recent history of endoscopy and a demarcated involvement of colonic segment are the most characteristic signs of glutaraldehyde-induced colitis. The typical clinical scenario is acute onset of lower abdominal pain, fever, and bloody stool.
View Article and Find Full Text PDFAcute rectocolitis following endoscopy in health check-up patients--glutaraldehyde colitis or ischemic colitis?
Int J Colorectal Dis
October 2009
Division of Colorectal surgery, Department of Surgery, Kaohsiung Veteran General Hospital, Kaohsiung City, Taiwan, 81346, Republic of China.
Purpose: Acute rectocolitis is a rare complication that follows endoscopy. It could be caused by glutaraldehyde or ischemic injury. The clinical, endoscopic, radiological, and pathological features of glutaraldehyde-induced colitis may mimic those of ischemic colitis.
View Article and Find Full Text PDFChemical colitis due to glutaraldehyde: case series and review of the literature.
Dig Dis Sci
December 2009
Department of Gastroenterology, Kartal State Hospital, No: 55/8 Bostanci, 34744 Istanbul, Turkey.
Chemical colitis can occur as a result of accidental contamination of endoscopes or by intentional/accidental administration of enemas containing various chemicals.We present three cases of glutaraldehyde induced colitis and review the cases in the literature. Glutaraldehyde induced colitis presents clinically with severe abdominal pain, bloody and mucoid diarrhea, rectal bleeding, and tenesmus 48-72 h after colonoscopy.
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