AI Article Synopsis
- The study investigated how chronic treatment with deoxycorticosterone acetate (DOCA) affects the enjoyment of rewards in rats with a sodium appetite.
- Rats treated with DOCA but without access to saline showed a decreased motivation for self-stimulation and reduced consumption of a tasty sucrose solution.
- Allowing access to saline during DOCA treatment prevented these negative effects, suggesting that unfulfilled sodium cravings can diminish the ability to experience pleasure from rewards.
Article Abstract
The authors tested the hypothesis that chronic treatment with a dose of deoxycorticosterone acetate (DOCA) known to elicit a robust sodium appetite can negatively affect the hedonic state of rats. Daily treatment with DOCA with no opportunity to ingest saline produced a rightward shift in the midpoint (effective current 50) of lateral hypothalamic self-stimulation (LHSS) current-response functions and reduced intakes of a palatable sucrose solution. Providing rats with 0.3 M saline during DOCA treatment prevented the rightward shift in LHSS response functions and the decrease in sucrose intake. The authors concluded that a chronic sodium appetite, with no opportunity to attenuate the appetite, can elicit a reduced responsiveness to reward.
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| http://dx.doi.org/10.1037/0735-7044.120.3.571 | DOI Listing |
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