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| http://dx.doi.org/10.1136/gut.2005.080960 | DOI Listing |
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Life and death of Yfh1: how cool is cold denaturation.
Q Rev Biophys
January 2025
Elettra Sincrotrone Trieste, Italy.
Yeast frataxin (Yfh1) is a small natural protein from yeast that has the unusual property of undergoing cold denaturation at temperatures above the freezing point of water when under conditions of low ionic strength. This peculiarity, together with remarkable resilience, allows the determination, for the whole protein as well as for individual residues, of the stability curve, that is the temperature dependence of the free energy difference between the unfolded and folded forms. The ease of measuring stability curves without the need to add denaturants or introduce destabilizing mutations makes this protein an ideal 'tool' for investigating the influence of many environmental factors on protein stability.
View Article and Find Full Text PDFThe Growing Phenomenon of 'Frozen' Virus Genome Sequences and Their Likely Origin in Research Facility Escapes.
Microorganisms
November 2024
Biology Department, University of Puerto Rico-Rio Piedras, San Juan 00931, Puerto Rico.
'Frozen' virus genome sequences are sampled from outbreaks and have unusually low sequence divergence when compared to genome sequences from historical strains. A growing number of 'frozen' virus genome sequences are being reported as virus genome sequencing becomes more common. Examples of 'frozen' sequences include the 1977 H1N1 'Russian' flu; Venezuelan Equine Encephalitis Virus from Venezuela and Colombia in 1995; E71 sequences from a Hand, Foot and Mouth outbreak in 2007-2009 in China; and a polio strain isolated in 2014 from Anhui, China.
View Article and Find Full Text PDFOxidative conversion of transthyretin in formalin-fixed clinical amyloid samples results in the formation of the His90Asp and His90Asn variants.
Amyloid
December 2024
Centre for Amyloidosis, Division of Medicine, University College London, London, UK.
Background: Proteomics is routinely used to type clinical amyloid deposits, and offers additional benefit of identifying genetic variants, which can be diagnostically useful. Reviewing the proteomics data for ATTR patients attending our Centre revealed an unusually large number of samples containing a rare pathogenic H90D TTR variant alongside the more common H90N variant.
Methods: These findings raised questions to their source.
Computed tomographic and endoscopic findings of multiple gastric anisakiasis.
Rev Esp Enferm Dig
December 2024
Medical Checkup, Naha City Hospital.
Article Synopsis
- A 36-year-old man experienced severe abdominal pain after eating raw fish, leading to a CT scan which indicated thickening of the gastric wall, raising suspicion for gastric anisakiasis.
- The endoscopy confirmed the presence of three Anisakis larvae in the gastric wall, which were successfully removed, alleviating the man's symptoms.
- Anisakiasis is an increasing global concern caused by consuming undercooked seafood; awareness among healthcare providers and proper seafood preparation is essential for prevention.
Heterotopic Gastric Mucosa in the Gallbladder: A Rare Case and Differential Diagnosis for a Gallbladder Polyp.
Cureus
October 2024
Pathology, The University of Alabama at Birmingham, Birmingham, USA.
Heterotopia or ectopic tissue refers to the presence of normal tissue in an abnormal location, away from its typical anatomic site. While heterotopia is not uncommon, its occurrence in the gallbladder is quite rare, and even more unusual is the presence of gastric heterotopia within the gallbladder. This case report describes a 41-year-old female patient with oxyntic-type heterotopic gastric mucosa in the proximal body of the gallbladder.
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