Spindle cells hemangioendotheloma generally reaches the extremities. Only one oropharyngeal localisation was described in the literature. We report the observation of a 41 years old patient who was operated twice for this localization. The patient presented in 2005 with a third recurrence with important local extension contraindicating surgical treatment. An external radiotherapy was carried out with a good local control of the lesion. In the light of this observation we will discuss physiopathology of this rare lesion and the various therapeutic options.
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