AI Article Synopsis
- Four new analogs of calcitriol were created, including side-chain amides (2 and 3) and hydroxamates (4 and 5).
- These analogs, despite missing the natural hormone's 25-OH group, show similar antiproliferative effects in lab tests as calcitriol.
- However, they are significantly less likely to increase calcium excretion in the body, being 20-40 times lower in that effect than calcitriol.
Article Abstract
Four new side-chain amide (2 and 3) and hydroxamate (4 and 5) analogs of the hormone calcitriol (1) have been prepared. Even though lacking the 25-OH group characteristic of natural calcitriol (1), analogs 2-4 are as antiproliferative in vitro as calcitriol (1) but are 20-40 times less calciuric in vivo than calcitriol (1).
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| http://dx.doi.org/10.1016/j.bmc.2006.05.050 | DOI Listing |
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