A cell entering the execution phase of apoptosis (regulated cell death) undergoes characteristic rearrangements, in which the cytoskeleton has major roles. Historically, this reorganisation has been attributed entirely to actomyosin contractility, with microtubule and intermediate filament systems both reported to be lost at an early stage. However, recent results indicate that microtubule networks re-form during the later stages of apoptosis and assist in the dispersal of nuclear and cellular fragments--steps that are thought to be important for preventing inflammation. Here, we discuss the roles of the cytoskeleton during apoptosis and challenge current thinking that actin is the sole functional component driving all major execution phase events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tcb.2006.05.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial.
Lancet Neurol
February 2025
Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada; Department of Cognitive Neurology, St Joseph's Health Care London, London, ON, Canada. Electronic address:
Background: No treatments exist for apathy in people with frontotemporal dementia. Previously, in a randomised double-blind, placebo-controlled, dose-finding study, intranasal oxytocin administration in people with frontotemporal dementia improved apathy ratings on the Neuropsychiatric Inventory over 1 week and, in a randomised, double-blind, placebo-controlled, crossover study, a single dose of 72 IU oxytocin increased blood-oxygen-level-dependent signal in limbic brain regions. We aimed to determine whether longer treatment with oxytocin improves apathy in people with frontotemporal dementia.
View Article and Find Full Text PDFA mobile interactive cognitive self-assessment scale for screening cognitive impairment due to Alzheimer's disease.
Age Ageing
January 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: A mobile cognition scale for community screening in cognitive impairment with rigorous validation is in paucity. We aimed to develop a digital scale that overcame low education for community screening for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and AD.
Methods: A mobile cognitive self-assessment scale (CogSAS) was designed through the Delphi process, which is feasible for the older population with low education.
Evading Antivirus Detection Using Fountain Code-Based Techniques for Executing Shellcodes.
Sensors (Basel)
January 2025
Department of Computer Science and Information Engineering, Chung Cheng Institute of Technology, National Defense University, Taoyuan 335009, Taiwan.
In this study, we propose a method for successfully evading antivirus detection by encoding malicious shellcode with fountain codes. The Meterpreter framework for Microsoft Windows 32-bit and 64-bit architectures was used to produce the shellcode used in this investigation. The experimental results proved that detection rates were substantially decreased.
View Article and Find Full Text PDFInvestigating the Detachment of Glazed Ceramic Tiles Used in Buildings: A Brazilian Case Study.
Materials (Basel)
January 2025
School of Engineering, Mackenzie Presbyterian University, São Paulo 01302-907, Brazil.
Ceramic detachments in cladding systems are indicative of adhesion loss between the ceramic tiles and the substrate or its adhesive mortar due to inadequate quality workmanship, the quality of the adhesive mortar or that of the ceramic material, whether acting simultaneously or not. The shear stresses resulting from the ceramic tiles' expansion due to humidity accelerate this process. There is a shortage of studies on the quality of ceramic tiles and adhesive mortars.
View Article and Find Full Text PDFThe Influence of Leather Type on Thermal and Smoke-Generating Properties.
Materials (Basel)
January 2025
Faculty of Safety Engineering and Civil Protection, Fire University, 52/54 Slowackiego Street, 01-629 Warsaw, Poland.
The main purpose of this article was to determine the smoke-generating and thermal properties of selected types of natural leather. Differences in the amount of smoke generated from the type of finish used in the technological processing of leather were observed. Research has shown that the burnt nubuck (367) sample with exposure at the heat flux intensity of 25 kW/m without the presence of a pilot burner flame achieved the highest value of the specific optical density D.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!