Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
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Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors.
Bioorg Med Chem Lett
August 2006
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, 23298-0540, USA.
Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
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