AI Article Synopsis
- Chronic restraint stress during early infection with Theiler's virus worsened acute CNS infections in both male and female mice.
- In the demyelinating phase, stress impacted disease progression differently based on sex: stressed males showed milder symptoms and better motor skills, while stressed females exhibited more severe issues.
- All mouse groups developed autoantibodies related to myelin proteins, indicating an immune response influenced by both stress and viral infection.
Article Abstract
Chronic restraint stress, administered during early infection with Theiler's virus, was found to exacerbate the acute CNS viral infection in male and female mice. During the subsequent demyelinating phase of disease (a model of multiple sclerosis), the effect of stress on disease progression was sex-dependent. Previously stressed male mice had less severe behavioral signs of the chronic phase, better rotarod performance and decreased inflammatory lesions of the spinal cord, while the opposite pattern was observed in females. In addition, mice in all groups developed autoantibodies to MBP, PLP139-151 and MOG33-55.
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| http://dx.doi.org/10.1016/j.jneuroim.2006.04.020 | DOI Listing |
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