The elemental uptake by Ulva lactuca (Sea lettuce), a marine macro-algae (chlorophyta, green alga) grown richly along KwaZulu-Natal coastline. The total elemental concentrations of seven important elements, namely manganese, iron, arsenic, boron, titanium, zinc and mercury, selected based on their abundance in U. lactuca were investigated for one year cycle (June 2002 to May 2003). The four selected sampling sites, Zinkwasi, Ballito, Treasure Beach and Park Ryrie are spread over 150 km wide along the KwaZulu-Natal coastline from North to South. The Ulva lectuca possess good manganese and arsenic accumulating ability and an excellent bio-indicator for most of the metals studied. A typical U. lectuca sample at Zinkwasi (in winter) recorded Mn (25.3 +/- 1.16 ppm), Fe (21.0 +/- 0.85 ppm), As (6.2 +/- 0.30 ppm), B (935 +/- 14 ppb), Ti (863 +/- 34 ppb), Zn (421 +/- 21 ppb), and Hg (61.3 +/- 1.2 ppb). The general trend found at all sites was high elemental concentrations in winter and a decrease in concentrations from winter to spring and summer. Iron uptake was lowest in summer and autumn at all sites. Ulva lactuca recorded highest mercury levels (>400 ppb) during the spring season at the Treasure Beach site near Durban.
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http://dx.doi.org/10.1080/10934520600623158 | DOI Listing |
Background: Emerging evidence suggests that air pollution exposure might diminish the cognitive health of older adults. Although many studies have reported that air pollution is associated with increased dementia risk, associations with the process of cognitive decline have been more heterogeneous.
Method: We used biennial data between 2000 to 2016 from respondents>65 years in the Health and Retirement Study (HRS), a national, population-based cohort in the United States, to study associations of air pollution with cognitive decline.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA.
Background: Household crowding is a longstanding focus of public health research; there is growing interest in its impact on dementia risk. In the US, household crowding is prevalent among low-income immigrant communities that have historically been excluded from dementia research. We evaluated the relationship between household crowding and neurocognitive performance among a novel cohort of middle-aged and primarily immigrant Latinas living in an underserved agricultural community and whether mental health or sleep duration might serve as potential mechanisms.
View Article and Find Full Text PDFJ Asthma
January 2025
Division of Pneumology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, AOU Sant'Andrea, 00189 Rome, Italy.
Objective: It remains unclear whether baseline FENO levels can predict response to anti-IL5/5R biologic treatment in patients with severe asthma.
Methods: We recruited 104 patients with severe eosinophilic asthma treated with anti-IL5/anti-IL5R for at least one year who had measured FeNO values before the beginning of anti-eosinophilic treatment. Population was divided into subjects with FeNO < 25 and ≥25 ppb.
Background: Therapeutic monoclonal antibodies targeting amyloid beta-protein (Ab), such as lecanemab, represent a promising approach for disease-modification in Alzheimer's disease (AD). Due to its relatively short half-life, lecanemab is given as a bi-monthly infusion (typically 10mg/kg). Binding to high abundance plasma proteins (PPB) can influence the pharmacokinetics of drugs in the blood, including their half-life.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia, Melbourne, VIC, Australia.
Background: Iron is vital for metabolism but can act as a catalyst for oxidative damage. Elevated brain iron, determined from biomarkers of iron (CSF ferritin and quantitative susceptibility mapping MRI) and from post-mortem measurement of brain iron, has been associated with accelerated cognitive decline in multiple Alzheimer's disease (AD) clinical, cohorts. These findings supported the hypothesis that treatment with the brain-permeable iron chelator deferiprone may be associated clinical benefit in AD.
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