[Estrogenic and androgenic effects of low dose raw water organics].
Wei Sheng Yan Jiu
Key Laboratory of the Public Health and Safety Ministry of Education Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Published: March 2006
Objective: To study the estrogenic and (anti)androgenic effects caused by low-dose raw water organic compounds.
Methods: The organic compounds from raw water was concentrated with solid-phase extraction. Rodent 3-day Uterotrophic Assay and Hershberger assay, the assays recommended in EPA Tier 1 Screening Program for EDCs, were employed to investigate estrogenic and (anti) androgenic effects of these chemical mixture exposure. Doses equivalent to human daily intake were administered to laboratory animals.
Results: Low-dose effects of water organic compounds,which refer to levels of human daily water intake, did not show a statistical difference of weights of mouse uterus and rat sexual accessory glands(SAG) from the negative control in Uterotrophic Assay and Hershberger Assay, except the height of uterus epithelial in 4.0 L / 60 kg was significant difference with negative control.
Conclusion: Based upon the water sample tested, it did not suggest that the low-dose raw water organic compounds exposure equivalent to people daily drinking water intake cause rodents (anti)androgenic in vivo effects, but it demonstrated a suspected estrogenic effect.
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