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http://dx.doi.org/10.1016/0006-3223(91)90139-d | DOI Listing |
Front Neurosci
April 2022
Neurosciences and Precision Medicine Research Institute "COSTAS STEFANIS" (UMHRI), University Mental Health, Athens, Greece.
Acoustic startle reflex (ASR) constitutes a reliable, cross-species indicator of sensorimotor and inhibitory mechanisms, showing distinct signature in cognitive aging, sex, and psychopathological characterization. ASR can be modulated by the prepulse inhibition (PPI) paradigm, which comprises the suppression of reactivity to a startling stimulus (pulse) following a weak prepulse (30- to 500-ms time difference), being widely linked to inhibitory capabilities of the sensorimotor system. If the prepulse-pulse tones are more clearly separated (500-2,000 ms), ASR amplitude is enhanced, termed as prepulse facilitation (PPF), reflecting sustained or selective attention.
View Article and Find Full Text PDFNeurosci Lett
July 2015
Department of Physiology, Emory University, Atlanta, GA 30322, United States; Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA 30322, United States. Electronic address:
While both glucocorticoids (the principal output of the hypothalamic-pituitary-adrenal axis) and oxidative stress have been implicated in outcomes due to an excessive or prolonged stress response, the precise mechanisms linking these two systems remain poorly elucidated. One potential mediator between the hypothalamic-pituitary-adrenal axis and oxidative stress is the hypoxia inducible factor-1 (HIF-1) pathway. HIF-1 is an oxygen-responsive transcription factor with diverse effects including changes in cellular metabolism.
View Article and Find Full Text PDFBiol Psychiatry
April 1991
Pharmacology Department, Kasturba Medical College, Karnataka South, India.
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