In the year 1986 the Clinical Department of the Institute of Biophysics of the Ministry of Health of the USSR was the main specialized center in the country for the treatment of radiation disease. More than 300 people involved into the Chernobyl nuclear power plant accident were submitted to a specialized clinical observation, and the acute radiation syndrome (ARS) was diagnosed in 115 of the patients. The author of the article worked as a chief of surgical team responsible for the radiation burns treatment.
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http://dx.doi.org/10.2298/vsp0605477b | DOI Listing |
Alzheimers Dement
December 2024
Stanford University, Stanford, CA, USA.
Background: Recent studies suggest that iron and neuroinflammation are key components of Alzheimer's Disease (AD) pathology. Ferrous Fe can cause oxidative stress and cellular toxicity, but it is unknown to what extent Fe is elevated in AD, in particular with the hippocampus. To answer this question, we quantified iron oxidation state in frozen human brain hippocampi.
View Article and Find Full Text PDFExp Neurol
December 2024
School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China. Electronic address:
Various factors and mechanisms, including radiation, initiate cellular senescence and are concurrent with the progression of various neurodegenerative diseases. Radiation-induced chromosomal aberrations and DNA integrity damage impact the processes of cellular growth, maturation, and aging. Astragaloside IV (AS-IV) has been documented to display significant neuroprotective effects on inflammation, oxidative stress, and cellular apoptosis; however, the precise neuroprotective mechanism of AS-IV against neuronal aging remains unclear.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
January 2025
Mabwell (Shanghai) Bioscience Co., Ltd, Shanghai, 201210, China.
Background: Targeting the TGF-β pathway in tumor therapy has proven challenging due to the highly context-dependent functions of TGF-β. Integrin αvβ8, a pivotal activator of TGF-β, has been implicated in TGF-β signaling within tumors, as demonstrated by the significant anti-tumor effects of anti-αvβ8 antibodies. Nevertheless, the expression profile of αvβ8 remains a subject of debate, and the precise mechanisms underlying the anti-tumor effects of anti-αvβ8 antibodies are not yet fully elucidated.
View Article and Find Full Text PDFJ Pers Med
December 2024
Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstrasse 27, 91054 Erlangen, Germany.
: Radiotherapy represents the only treatment option for patients with inoperable endometrial cancer (EC). The aim of our study was to evaluate the efficacy and safety of brachytherapy (BT) in this selected patient population. : Between 1990 and 2019, 18 patients with inoperable EC in stage FIGO I-IV were treated with intracavitary brachytherapy using the "Heyman Packing technique".
View Article and Find Full Text PDFCureus
November 2024
Department of Pulmonary Medicine, King's College Hospital, Dubai, ARE.
Middle Eastern countries, such as the United Arab Emirates and Oman, are affected by frequent dust storms and extreme hot climatic conditions, which can exacerbate respiratory conditions. These environmental factors are particularly injurious to asthmatic patients, as they can aggravate small airway disease (SAD), leading to increased morbidity and healthcare challenges. The evaluation of maximal mid-expiratory flow (MEF-25) as a diagnostic and therapeutic tool for early-stage small airway dysfunction is of significant clinical importance, particularly in hot and arid metropolitan environments where dusty conditions exacerbate pulmonary issues.
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