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Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.
Elife
January 2025
Cell Biology, Hospital for Sick Children, Toronto, Canada.
Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell size checkpoints, which delay cell cycle progression in small cells, and size-dependent regulation of mass accumulation rates (Ginzberg et al., 2018).
View Article and Find Full Text PDFClinical Practice Guidelines for Topical NSAIDs in the Treatment of Sports Injuries.
J Evid Based Med
January 2025
Department of Orthorpedics and Sports Medicine, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat sports injuries, but evidence-based medical guidance for their standardized and rational use is lacking. This guideline working group identified clinically important issues, obtained the full opinions of patients and clinical staff, and discussed them with the expert group. Based on evidence from the literature, the "clinical practice guidelines for topical NSAIDs in the treatment of sports injuries" were formulated following the methods and principles of international guidelines.
View Article and Find Full Text PDFCountry-specific key lifestyle factors and health outcomes for resource allocation in the general population: a network analysis across 29 countries.
J Glob Health
January 2025
Medical-surgical Nursing Department, Faculty of Nursing, Cairo University, Cairo, Egypt.
Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.
Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.
Flexible Triboelectric Nanogenerator Patch for Accelerated Wound Healing Through the Synergy of Electrostimulation and Photothermal Effect.
Small
January 2025
Guangzhou Institute of Blue Energy, Knowledge City, Huangpu District, Guangzhou, 510555, P. R. China.
Physiological wound healing process can restore the functional and structural integrity of skin, but is often delayed due to external disturbance. The development of methods for promoting the repair process of skin wounds represents a highly desired and challenging goal. Here, a flexible, self-powered, and multifunctional triboelectric nanogenerator (TENG) wound patch (e-patch) is presented for accelerating wound healing through the synergy of electrostimulation and photothermal effect.
View Article and Find Full Text PDFEnvironmental changes and uplift of the Qinghai-Tibet Plateau drive genetic diversification and speciation of the birds.
Yi Chuan
January 2025
Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Being the most magnificent plateau in elevation and size on Earth, the Qinghai-Tibet Plateau has a profound impact on biodiversity due to the unique geographic and climatic conditions. Here we review the speciation patterns and genetic diversity of the birds from the Qinghai-Tibet Plateau in relation to the geological history and climatic changes. First, the uplift of the Qinghai-Tibet Plateau forms a geographic barrier and promotes interspecific and intraspecific genetic differentiation.
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