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Human brain aging is associated with dysregulation of cell type epigenetic identity.
Geroscience
December 2024
Department of Ecology, Evolution, and Marine Biology, Department of Molecular, Cellular, and Cell Biology, Neuroscience Research Institute, University of California, Santa Barbara, CA, 93106, USA.
Significant links between aging and DNA methylation are emerging from recent studies. On the one hand, DNA methylation undergoes changes with age, a process termed as epigenetic drift. On the other hand, DNA methylation serves as a readily accessible and accurate biomarker for aging.
View Article and Find Full Text PDFAn alternative recommendation for design eccentricity by consideration of uncoupled frequency ratio.
Sci Rep
December 2024
Department of Civil Engineering, Mehmet Akif Ersoy University, Burdur, Turkey.
Civil structures are prone to dynamic loadings such as strong winds or ground excitations where torsion becomes an ongoing issue. This arises from a lack of coincidence of the center of mass (CM) and rigidity (CR), known as eccentricity. Seismic design codes often introduce two types of eccentricity: inherent (geometric) and accidental.
View Article and Find Full Text PDFStructural and functional determination of peptide versus small molecule ligand binding at the apelin receptor.
Nat Commun
December 2024
Experimental Medicine & Immunotherapeutics, University of Cambridge, Cambridge, UK.
We describe a structural and functional study of the G protein-coupled apelin receptor, which binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate cardiovascular development and function. Characterisation of naturally occurring apelin receptor variants from the UK Genomics England 100,000 Genomes Project, and AlphaFold2 modelling, identifies T89 as important in the ELA binding site, and R168 as forming extensive interactions with the C-termini of both peptides. Base editing to introduce an R/H168 variant into human stem cell-derived cardiomyocytes demonstrates that this residue is critical for receptor binding and function.
View Article and Find Full Text PDFChinese translation, cross-cultural adaptation, and psychometric validation of patient-reported outcome measurement- questionnaire about gynecological and pelvic pain symptoms (ENDOPAIN-4D).
Eur J Obstet Gynecol Reprod Biol
December 2024
Gynecology Ward 1, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
Objectives: The aim of this study was to cross-culturally translate a questionnaire about gynecological and pelvic pain symptoms (ENDOPAIN-4D) patient-reported outcome measurement (PROM) into Chinese and evaluate its reliability and validity.
Methods: The questionnaire was translated according to Brislin's classic back-translation model. We conducted cultural debugging through cognitive interviews with Chinese-speaking women who had experienced pelvic pain (n = 24).
Animals as Architects: Building the Future of Technology-Supported Rehabilitation with Biomimetic Principles.
Biomimetics (Basel)
November 2024
REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium.
Rehabilitation science has evolved significantly with the integration of technology-supported interventions, offering objective assessments, personalized programs, and real-time feedback for patients. Despite these advances, challenges remain in fully addressing the complexities of human recovery through the rehabilitation process. Over the last few years, there has been a growing interest in the application of biomimetics to inspire technological innovation.
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