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Distribution and invasiveness of Streptococcus pneumoniae serotypes in Switzerland, a country with low antibiotic selection pressure, from 2001 to 2004. | LitMetric

AI Article Synopsis

  • A study analyzed 2,388 invasive and 1,540 colonizing Streptococcus pneumoniae isolates from 2001 to 2004 to understand the serotype-specific epidemiology, which is crucial for vaccination strategies.
  • The research identified that certain serotypes have a higher potential for invasiveness (e.g., serotypes 1, 4, 7F) while others are more commonly associated with colonization (e.g., serotypes 3, 6A, 19F).
  • Additionally, pediatric serotypes were found to be more prevalent in younger children and older adults, with geographic variations in antibiotic resistance patterns and implications for the effectiveness of the 7-valent conjugate vaccine.

Article Abstract

To describe the serotype-specific epidemiology of colonizing and invasive Streptococcus pneumoniae isolates, which is important for vaccination strategies, we analyzed a total of 2,388 invasive and 1,540 colonizing S. pneumoniae isolates collected between January 2001 and December 2004 within two nationwide surveillance programs. We found that the relative rank orders of the most frequent serotypes (serotypes 1, 3, 4, 6B, 7F, 14, 19F, and 23F) differed among invasive and colonizing isolates. Serotypes 1, 4, 5, 7F, 8, 9V, and 14 had increased invasive potential, and serotypes/serogroups 3, 6A, 7, 10, 11, 19F, and 23F were associated with colonization. The proportion of pediatric serotypes was higher among children < 5 years old (48.5%) and persons > 64 years old (34.1%) than among other age groups (29.1%); it was also higher in West Switzerland (40.2%) than in other geographic regions (34.7%). Likewise, serotype-specific proportions of penicillin-resistant isolates for types 6B, 9V, 14, and 19F were significantly higher in West Switzerland. The relative frequency of pediatric serotypes corresponded with antibiotic consumption patterns. We conclude that the epidemiology of invasive and colonizing S. pneumoniae isolates is influenced by the serotype-specific potential for invasiveness, and therefore, surveillance programs should include colonizing and invasive S. pneumoniae isolates. Antibiotic selection pressure determines the serotype distribution in different age groups and geographic regions and therefore the expected direct and indirect effects of the 7-valent conjugate vaccine.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489397PMC
http://dx.doi.org/10.1128/JCM.00275-06DOI Listing

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