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Secondary Polymyalgia Rheumatica Following SARS-CoV-2 Infection.
Acta Med Okayama
December 2024
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
An 81-year-old Japanese man with a medical history of diabetes mellitus and hypertension was diagnosed with the novel coronavirus disease 2019 (COVID-19). The patient developed pain in the bilateral shoulders and hips 3 days after the disease onset and presented to our outpatient clinic after 1 month. Referring to diagnostic criteria, we diagnosed him with polymyalgia rheumatica (PMR).
View Article and Find Full Text PDFHuman Genetic Evidence to Inform Clinical Development of IL-6 Signaling Inhibition for Abdominal Aortic Aneurysm.
Arterioscler Thromb Vasc Biol
December 2024
Sequoia Genetics, London, United Kingdom (S.B., H.T.C., D.G.).
Article Synopsis
- Abdominal aortic aneurysm (AAA) is a major health issue with no effective medical treatments, so researchers are exploring IL-6 signaling inhibition as a potential therapy.
- The study analyzed genetic data from large cohorts, finding strong associations between genetic variants linked to IL-6 signaling and reduced AAA risk.
- The results suggest that targeting IL-6 signaling could be a viable approach for AAA treatment, though it may not be effective for other aneurysm types.
Comprehensive analysis of rheumatic diseases, comorbidities, and mortality in geriatric population: Real-world data of 515 patients in a single rheumatology clinic.
Medicine (Baltimore)
November 2024
Department of Medicine, Rheumatology, School of Medicine, Halic University, Istanbul, Turkey.
Article Synopsis
- Geriatric patients (aged 65 and older) present different patterns of rheumatic diseases compared to younger patients, with significantly higher rates of rheumatoid arthritis, polymyalgia rheumatica, crystal arthritis, and osteoarthritis.
- They also experience more comorbidities such as hypertension, diabetes, and osteoporosis, indicating a greater burden of chronic health issues.
- Treatment approaches vary, with geriatric patients using more corticosteroids and traditional synthetic treatments but fewer biological treatments, and they have higher mortality rates linked to conditions like cancer and heart disease.
Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies.
BMC Genomics
November 2024
Precision Medicine & Computational Biology, Sanofi, Cambridge, MA, USA.
Background: Therapeutic targets supported by genetic evidence from genome-wide association studies (GWAS) show higher probability of success in clinical trials. GWAS is a powerful approach to identify links between genetic variants and phenotypic variation; however, identifying the genes driving associations identified in GWAS remains challenging. Integration of molecular quantitative trait loci (molQTL) such as expression QTL (eQTL) using mendelian randomization (MR) and colocalization analyses can help with the identification of causal genes.
View Article and Find Full Text PDFAnalysis of musculoskeletal ultrasound findings and cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica.
Immunol Med
November 2024
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
We sought to clarify the musculoskeletal ultrasound (MSUS) findings and serum concentrations of cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica (GC-R PMR). Patients with PMR admitted to Nagasaki University Hospital ( = 41) were enrolled. MSUS of both shoulder joints was performed in 36 patients.
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