AI Article Synopsis
- Conventional treatments for mantle cell lymphoma (MCL) often lead to limited success, prompting the use of hematopoietic stem cell transplants (HSCT), which showed promising outcomes in a study involving 30 patients.
- In this study, 83% of patients achieved complete remission after HSCT, with varied survival rates indicating slightly better outcomes for allogeneic transplants compared to autologous.
- The research highlights that while HSCT for MCL can provide extended disease control and long-term survival, there are risks involved, with some patients experiencing mortality related to the transplant or disease.
Article Abstract
Conventional treatment of mantle cell lymphoma (MCL) yields modest responses and short remissions. We report 30 hematopoietic stem cell transplants (HSCT) for MCL: 13 autologous, 10 allogeneic myeloablative, and 7 nonablative. After a median 1.2 years from diagnosis (range 0.5 to 4.7) and a median of 2 pre-HSCT chemotherapeutic regimens (range 1 to 5), their median age at HSCT was 52 years (range 37 to 67). Eleven patients (41%) were in first remission, 11 (41%) were in second remission, and 7 (25%) had resistant disease. Four died early. Nineteen achieved CR (83%) and 4 PR (17%). With median 2.7 years of follow-up, 5-year overall survival (OS) was 42% (95% CI 11-73%) after autologous versus allogeneic at 49% (95% CI 22-76%). Five-year progression-free survival (PFS) was 31% (95% CI 3-59%) and 50% (95% CI 24-76%) for autologous and allogeneic HSCT, respectively. Fourteen died: 3 from sepsis, 1 acute GVHD, 10 MCL. No autologous transplant-related deaths occurred. Allogeneic transplant-related mortality was 29% (95% CI 6-52%) at 1 and 5 years. HSCT for MCL can yield extended disease control and long-term survival.
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| http://dx.doi.org/10.1002/ajh.20646 | DOI Listing |
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