AI Article Synopsis
- Oxidative stress may contribute to aging and increased risk of death, so a study was conducted on 154 non-smoking elderly individuals in Spain to assess oxidative status and its relation to mortality.
- Baseline levels of various antioxidants and lipid peroxidation markers were measured, with an average survival time of 4.3 years, during which 20.1% of participants died.
- The study found that higher levels of malondialdehyde (MDA) were linked to increased mortality, while higher levels of antioxidants like alpha-tocopherol and SOD were associated with better survival rates, suggesting that lower oxidative stress and better antioxidant protection could reduce the risk of dying.
Article Abstract
Oxidative stress has been related to ageing and risk of death. To determine whether oxidative status was associated with all-cause risk of death we carried out a prospective study in 154 non-smoking Spanish elderly without major illness. Baseline glutathione peroxidase (GPx) and superoxide dismutase (SOD) were analysed in plasma and erythrocytes. alpha-tocopherol, beta-carotene, lycopene and retinol were determined in serum samples and malondialdehyde (MDA), as a lipid peroxidation marker, in plasma. Mean survival time was 4.3 years. A total of 31 death cases (20.1%) occurred during the follow-up. Plasma-MDA predicted mortality independently of all other variables, while erythrocyte-SOD (e-SOD), beta-carotene and alpha-tocopherol were positively associated with survival. alpha-tocopherol and MDA were revealed as independent predictors in a joint survival model, being the group with low MDA and high alpha-tocopherol that with the lowest mortality. In conclusion, a higher risk of death was associated with increased lipid peroxidation and lower antioxidant defenses.
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| http://dx.doi.org/10.1080/10715760600580470 | DOI Listing |
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