AI Article Synopsis
- The study details the synthesis of closo- and nido-carboranylchlorins 4 and 5 from a previously known carboranylporphyrin.
- Nido-carboranylporphyrin 5 showed low toxicity without light (IC50 > 500 µM) but became toxic in the presence of red light (IC50 = 80 µM at a specific light dose).
- Carboranylchlorin 5 was absorbed more efficiently by human glioma T98G cells compared to chlorin e6, with a preference for localization in cell lysosomes, indicating its potential as a dual sensitizer for tumor treatments like photodynamic therapy (PDT) and boron neutron capture therapy (BNCT
Article Abstract
The syntheses of closo- and nido-carboranylchlorins 4 and 5 from a known carboranylporphyrin are described. Water-soluble nido-carboranylporphyrin 5 was found to have very low dark cytotoxicity (IC50 > 500 microM using a MTT-based assay) but to be toxic in the presence of red light (IC50 = 80 microM at 0.55 J/cm2 light dose). Under the same experimental conditions, carboranylchlorin 5 was taken up by human glioma T98G cells to a significantly higher extent than chlorin e6, a chlorophyll degradation product. The preferred sites of subcellular localization of carboranylchlorin 5 were found to be the cell lysosomes. Our results suggest that carboranylchlorin 5 is a promising new dual sensitizer for the PDT and BNCT treatment of tumors.
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| http://dx.doi.org/10.1016/j.bmc.2006.05.026 | DOI Listing |
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