Reduction of acid tolerance by tetracycline in Escherichia coli expressing tetA(C) is reversed by cations.

Appl Environ Microbiol

Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin, 1925 Willow Dr., Madison, WI 53706-1187, USA.

Published: June 2006

When tetracycline was present, tetA(C) reduced acid tolerance, suppressed rpoS expression, and increased the concentration of total soluble proteins in stationary-phase Escherichia coli. The suppression of acid tolerance was reversed by 85 mM sodium, potassium, magnesium, and calcium ions but not by 85 mM sucrose. Implications for using TetA(C) are discussed.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489608PMC
http://dx.doi.org/10.1128/AEM.02519-05DOI Listing

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