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Rathke cleft cyst with squamous metaplasia and activating mutations of mitogen-activated protein kinase signaling: illustrative case.
J Neurosurg Case Lessons
January 2025
Department of Neurological Surgery, University of California, San Diego, La Jolla, California.
Background: Rathke cleft cysts (RCCs) are benign sellar/suprasellar lesions that result from mucin-secreting vestigial remnants within the pars intermedia of the pituitary gland. When symptomatic, they can present with retro-orbital headaches, visual field defects, and/or pituitary dysfunction.
Observations: A 35-year-old female presented with subacute retro-orbital headache, right ptosis, and blurred vision.
Rathke's cleft cysts: from pathophysiology to management.
Neurosurg Rev
September 2024
Department of Neurosurgery, New York University Grossman School of Medicine, New York City, NYC, USA.
Rathke's cleft cysts (RCCs) are benign, non-neoplastic lesions located in the sellar and suprasellar regions of the brain, originating from remnants of Rathke's pouch, an embryonic precursor to the anterior pituitary gland. Although RCCs are frequently asymptomatic and discovered incidentally during imaging studies, they can present with a variety of symptoms, including headaches, visual disturbances, and endocrine dysfunction due to the compression of adjacent neural structures. The management of RCCs is particularly challenging, as the decision to pursue conservative monitoring or surgical intervention depends heavily on the cyst's size, growth potential, and the severity of symptoms.
View Article and Find Full Text PDFStaged Surgical Treatment of the Giant Pituitary Neuroendocrine Tumors.
World Neurosurg
December 2024
Department of Neurological Surgery at Taihe Hospital, Hubei University of Medicine, Shiyan, China. Electronic address:
Objective: To investigate the long-term clinical outcomes of staged surgical resection in giant Pituitary Neuroendocrine Tumors.
Methods: We performed a retrospective analysis of the clinical data of 16 patients who underwent surgery. The patients were diagnosed and underwent surgery at the Department of Neurosurgery of Shiyan Taihe Hospital from January 2013 to March 2021.
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