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| http://dx.doi.org/10.1042/bj0730261 | DOI Listing |
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Canavanine Content Quantification in Processed Bitter Vetch () and Its Application as Flour in Breads: An Analysis of Nutritional and Sensory Attributes.
Foods
August 2024
The Levi Eshkol School of Agriculture, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Bitter vetch ( Willd.) is a traditional Mediterranean-West Asian legume, mainly used as livestock feed because of its toxic non-proteinogenic amino acid, canavanine. However, historical sources suggest its past human consumption.
View Article and Find Full Text PDFA standalone editing protein deacylates mischarged canavanyl-tRNAArg to prevent canavanine incorporation into proteins.
Nucleic Acids Res
March 2023
Department of Chemistry, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany.
Error-free translation of the genetic code into proteins is vitally important for all organisms. Therefore, it is crucial that the correct amino acids are loaded onto their corresponding tRNAs. This process is highly challenging when aminoacyl-tRNA-synthetases encounter structural analogues to the native substrate like the arginine antimetabolite canavanine.
View Article and Find Full Text PDFCanavanine, the δ-oxa-analogue of arginine, is produced as one of the main nitrogen storage compounds in legume seeds and has repellent properties. Its toxicity originates from incorporation into proteins as well as arginase-mediated hydrolysis to canaline that forms stable oximes with carbonyls. So far no pathway or enzyme has been identified acting specifically on canavanine.
View Article and Find Full Text PDFChemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in .
G3 (Bethesda)
December 2020
Department of Biochemistry, The University of Western Ontario, London, Canada
Non-proteinogenic amino acids, such as the proline analog L-azetidine-2-carboxylic acid (AZC), are detrimental to cells because they are mis-incorporated into proteins and lead to proteotoxic stress. Our goal was to identify genes that show chemical-genetic interactions with AZC in and thus also potentially define the pathways cells use to cope with amino acid mis-incorporation. Screening the yeast deletion and temperature sensitive collections, we found 72 alleles with negative chemical-genetic interactions with AZC treatment and 12 alleles that suppress AZC toxicity.
View Article and Find Full Text PDFCombinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms.
Cells
September 2020
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland.
Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids. Here, we evaluated, in vitro, a novel combinatory antiglioblastoma approach based on arginine deprivation and canavanine, an arginine analogue of plant origin, using two human glioblastoma cell models, U251MG and U87MG.
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