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| http://dx.doi.org/10.1042/bj0292522 | DOI Listing |
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GnRH pulse generator activity in mouse models of polycystic ovary syndrome.
Elife
January 2025
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Article Synopsis
- One in ten women of reproductive age have PCOS, characterized by subfertility, high LH levels, and potential dysfunction in the kisspeptin neurons that regulate GnRH.
- Researchers studied the GnRH pulse generator in two mouse models of PCOS: the peripubertal androgen (PPA) model showed fewer synchronized neuron events, while the prenatal androgen (PNA) model revealed variable GnRH activity but cyclical patterns indicating complexity.
- Findings indicate that in the PNA model, ARN neurons had increased activity during specific stages and less sensitivity to progesterone, highlighting the need to understand GnRH regulation in PCOS-related conditions.
Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET.
J Transl Med
November 2024
Department of Paediatric Haematology and Oncology, University Children's Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Background: Pituitary neuroendocrine tumors (PitNET) are among the most common intracranial tumors. Despite a frequent benign course, aggressive behavior can occur. Tumor behavior is known to be under the influence of the tumor microenvironment (TME).
View Article and Find Full Text PDFGnRH-Gonadotropes Interactions Revealed by Pituitary Single-cell Transcriptomics in Zebrafish.
Endocrinology
October 2024
Institute of Marine & Environmental Technology, Department of Marine Biotechnology, University of Maryland Baltimore County, Baltimore, MD 21202, USA.
GnRH governs reproduction by regulating pituitary gonadotropins. Unlike most vertebrates, gnrh-/- zebrafish are fertile. To elucidate the role of the hypophysiotropic-Gnrh3 and other mechanisms regulating pituitary gonadotropes, we profiled the gene expression of all individual pituitary cells of wild-type and gnrh3-/- adult female zebrafish.
View Article and Find Full Text PDFIdentification and Characterization of Novel FSHR Copy Number Variations Causing Premature Ovarian Insufficiency.
Am J Med Genet A
November 2024
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S1085, Rennes, France.
Article Synopsis
- FSH (follicle stimulating hormone) is crucial for fertility, ovarian function, and can cause reproductive disorders like OHSS and POI when variations occur in its receptor (FSHR).
- A case study identified a patient with primary amenorrhea and delayed puberty who carried two deletions in the FSHR gene, leading to complete loss of function of both alleles.
- The research highlights the complexity of genetic factors in reproductive health and suggests incorporating CNV (copy number variation) detection in diagnosing POI for improved patient care.
Evaluation of male reproductive hormones of Kalahari Red and Kalawad goat bucks as affected by age and season under tropical conditions.
Trop Anim Health Prod
October 2024
Department of Animal Physiology, Federal University of Agriculture, (FUNAAB), Abeokuta, P.M.B 2240, Nigeria.
Comprehensive understanding of reproductive hormones and environmental cues with their relationship is essential for efficient production in livestock sectors involving either assisted or natural reproductive methods. This study evaluated the effects of age and seasonal-associated changes in the blood concentrations of testosterone and follicle stimulating hormone (FSH) of male Kalahari Red (KR) and Kalawad (KW)-crossbred goats. Based on a 2 × 3 × 4 factorial arrangement, a total of 42 bucks (KR n = 21 and KW n = 21) were allotted into three age groups (> 1 ≤ 2 years, > 2 ≤ 3 years and > 3 ≤ 4 years) with seven KR bucks and seven KW bucks each per age group; reared under different seasons (early rainy, late rainy, early dry and late dry).
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