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Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cells.
Cell Mol Biol Lett
January 2025
School of Medicine, Shanghai University, Shanghai, 200444, China.
Background: Interfacial heterogeneity is widely explored to reveal molecular mechanisms of force-mediated pathways due to biased tension. However, the influence of cell density,, curvature, and interfacial heterogeneity on underlying pathways of mechanotransduction is obscure.
Methods: Polydimethylsiloxane (PDMS)-based stencils were micropatterned to prepare the micropores for cell culture.
Transition to Piscivory Seen Through Brain Transcriptomics in a Juvenile Percid Fish: Complex Interplay of Differential Gene Transcription, Alternative Splicing, and ncRNA Activity.
J Exp Zool A Ecol Integr Physiol
December 2024
Institute of Hydrobiology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic.
Pikeperch (Sander Lucioperca) belongs to main predatory fish species in freshwater bodies throughout Europe playing the key role by reducing planktivorous fish abundance. Two size classes of the young-of-the-year (YOY) pikeperch are known in Europe and North America. Our long-term fish survey elucidates late-summer size distribution of YOY pikeperch in the Lipno Reservoir (Czechia) and recognizes two distinct subcohorts: smaller pelagic planktivores heavily outnumber larger demersal piscivores.
View Article and Find Full Text PDFGenes Related to Motility in an Ionizing Radiation and Estrogen Breast Cancer Model.
Biology (Basel)
October 2024
Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.
Article Synopsis
- Breast cancer is the leading cause of cancer-related deaths among women, influenced by environmental radiation and hormonal factors, with cell motility playing a key role in its development and spread.
- Research on an experimental breast cancer model exposed to radiation and estrogen revealed increased gene expression related to cell motility in irradiated cells compared to controls and malignant lines.
- An analysis of patient data indicated that certain genes associated with motility showed varying expression levels in normal versus tumor tissues, highlighting their potential impact on patient survival and therapy options based on hormone receptor status.
An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells.
EMBO J
January 2025
CRBM, University of Montpellier and CNRS, Montpellier, 34293, France.
Article Synopsis
- EpCAM and Trop2 are cell surface markers linked to carcinoma, affecting myosin-based cell behaviors essential for adhesion and migration, but their specific roles in cancer metastasis are not well understood.
- The study uses MCF7 breast cancer cell spheroids to explore how different levels of EpCAM and Trop2 influence cell spreading and cohesion, revealing that depleting EpCAM promotes spreading while depleting Trop2 inhibits it.
- The findings suggest that EpCAM and Trop2 work together to regulate cell contractility and adhesion by affecting cortical tension at cell interfaces, indicating their potential function as a mechanostat that modulates cell behavior in cancer progression.
Viscosity regulates cell spreading and cell-extracellular matrix interactions.
FEBS J
November 2024
Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Fluid viscosity and osmolarity are among some of the underappreciated mechanical stimuli that cells can detect. Abnormal changes of multiple fluidic factors such as viscosity and osmolarity have been linked with diseases such as cystic fibrosis, cancer, and coronary heart disease. Changes in viscosity have been recently suggested as a regulator of cell locomotion.
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